PP2A Subunit B' Isoform PR53: A Potential Drug Target and Biomarker

Target Name: PTPA

NCBI ID: G5524

PTPA

PP2A Subunit B' Isoform PR53: A Potential Drug Target and Biomarker

Phosphatidylinositol 4-phosphate (PIP2) is a signaling molecule that plays a crucial role in various cellular processes, including cell signaling, intracellular signaling, and cell survival. One of the key subunits of PIP2, known as PP2A subunit B' isoform PR53, has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

PP2A Subunit B' isoform PR53: Structure and Function

PP2A is a protein that consists of two subunits, PP2A subunit A (also known as B' isoform) and PP2A subunit B. The subunits are held together by a disulfide bond, and the N-terminus of each subunit contains a tyrosine residue, which is important for the subunit's stability and function. PP2A is a critical protein for various cellular processes, including cell signaling, intracellular signaling, and cell survival.

PP2A Subunit B' isoform PR53 is a 194-amino acid protein that is highly conserved between the two subunits of PP2A. It has a unique structure that consists of a catalytic center, a nucleotide-binding domain, and a C-terminal hypervariable region (HVR). The catalytic center is the site of the protein's catalytic activity and is responsible for the formation of the protein's disulfide bond. The nucleotide-binding domain is responsible for binding to nucleotides, which is essential for the protein's function in intracellular signaling. The C-terminal HVR is responsible for the protein's stability and interacts with various cellular signaling pathways.

PP2A Subunit B' isoform PR53 has been shown to play a crucial role in various cellular processes, including cell signaling, intracellular signaling, and cell survival. It has been shown to be involved in various signaling pathways, including the PI3K/Akt signaling pathway, the TOR signaling pathway, and the NF-kappa-B signaling pathway.

In addition to its role in intracellular signaling, PP2A Subunit B' isoform PR53 has also been shown to play a role in the regulation of various cellular processes, including cell adhesion, migration, and survival. It has been shown to be involved in the regulation of cell adhesion by affecting the formation of tight junctions and the maintenance of cell-cell contacts. It has also been shown to play a role in the regulation of cell migration by affecting the migration of cancer cells.

PP2A Subunit B' isoform PR53 has also been shown to be involved in the regulation of various signaling pathways that are involved in cardiovascular diseases, including the regulation of blood pressure, cholesterol levels, and blood vessel diameter. It has been shown to play a role in the regulation of blood pressure by affecting the formation of blood vessels and the regulation of ion channels in the heart. It has also been shown to play a role in the regulation of cholesterol levels by affecting the levels of low-density lipoprotein (LDL) cholesterol in the blood.

Drug Targeting and Biomarker

PP2A Subunit B' isoform PR53 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Drugs that target PP2A Subunit B' isoform PR53 have been shown to have various therapeutic effects, including the inhibition of cell proliferation, the inhibition of angiogenesis, and the inhibition of inflammation.

One of the most promising drugs that targets PP2A Subunit B' isoform PR53 is a small molecule inhibitor, known as PIP2 inhibitor, which is designed to inhibit the activity of PP2A Subunit B' isoform PR53. PIP2 inhibitor has been shown to have therapeutic effects in various

Protein Name: Protein Phosphatase 2 Phosphatase Activator

Functions: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A

The "PTPA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PTPA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets