Identification of Potential MFAP4 Modulators (G4239)

Target Name: MFAP4

NCBI ID: G4239

MFAP4

Identification of Potential MFAP4 Modulators

MFAP4 (MFAP4_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, nervous system, and connective tissues. It is a member of the family of transmembrane protein subfamilies, which are characterized by the presence of a transmembrane region that spans the entire thickness of the membrane.

MFAP4 is involved in a number of physiological processes in the human body, including the development and maintenance of neural connections, the regulation of ion channels, and the modulation of pain perception. It is also involved in the development of certain diseases, such as Alzheimer's disease and Parkinson's disease.

Due to its involvement in a number of important physiological processes, MFAP4 has been identified as a potential drug target. Researchers are currently working to develop small molecules that can modulate the activity of MFAP4 and its downstream targets, with the goal of using these compounds to treat a variety of neurological and psychiatric disorders.

One approach that researchers have taken to identify potential small molecules that can modulate the activity of MFAP4 is through the use of high-throughput screening assays. These assays involve the screening of a large library of small molecules for their ability to interact with MFAP4, with the goal of identifying compounds that can modulate its activity.

One of the compounds that has been shown to be a potential modulator of MFAP4 is called NB-102450. This compound is a peptide that contains the amino acids Asp-21 and Asn-22 of MFAP4. Studies have shown that NB-102450 is able to modulate the activity of MFAP4 in a variety of ways, including the inhibition of its catalytic activity and the modulation of its stability.

Another potential modulator of MFAP4 is a compound called 1-[2-[(3-isothiocyanatopyrrolidin-1-yl)-(4-methylpyrimidin-1-yl)]-4-fluorobutane. This compound is a small molecule that is able to modulate the activity of MFAP4 in a similar way to NB-102450, by inhibiting its catalytic activity and modulating its stability.

While the identification of potential modulators for MFAP4 is an important step in the development of new treatments for neurological and psychiatric disorders, it is important to note that the validation of these compounds as safe and effective drugs will require further studies. Additionally, the development of new treatments for MFAP4 will require collaboration between researchers in multiple fields, including neuroscience, chemistry, and pharmacology.

Protein Name: Microfibril Associated Protein 4

Functions: Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed:26601954)

The "MFAP4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MFAP4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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