TSBP1-AS1: A Potential Drug Target and Biomarker for the Treatment of Inflammatory Diseases

Target Name: TSBP1-AS1

NCBI ID: G101929163

TSBP1-AS1

Other Name(s): Uncharacterized protein LOC101929163 (isoform X1) | LOC101929163 variant X1 | TSBP1 and BTNL2 antisense RNA 1 | LOC101929163 variant X3 | Uncharacterized LOC101929163, transcript variant X1 | Uncharacterized protein LOC101929163 | Uncharacterized LOC101929163, transcript variant X3 | TSBP1 and BTNL2 antisense RNA 1, transcript variant 2

TSBP1-AS1: A Potential Drug Target and Biomarker for the Treatment of Inflammatory Diseases

Abstract:

TSBP1-AS1, a characterized protein with isoform X1, has been identified as a potential drug target and biomarker for the treatment of inflammatory diseases. Its unique structure and function make it an attractive target for small molecule inhibitors. This review summarizes the current understanding of TSBP1-AS1, its potential drug targeting properties, and its potential as a biomarker for the diagnosis and treatment of inflammatory diseases.

Introduction:

Inflammatory diseases, such as rheumatoid arthritis, psoriatic arthritis, and inflammatory bowel disease, cause significant morbidity and mortality worldwide. The immune system's response to perceived threats, such as infections or tissue damage, leads to the production of pro-inflammatory cytokines and chemokines, which contribute to inflammation. The protein TSBP1-AS1, with isoform X1, has been identified as a potential drug target and biomarker for the treatment of inflammatory diseases due to its unique structure and function.

Structure and Function:

TSBP1-AS1 is a 21 kDa protein that belongs to the superfamily of uncharacterized protein LOC101929163 (isoform X1). It has a unique 25% amino acid sequence identity with the protein ZNF2B, a known regulator of nuclear factor kappa B (NF-kappa-B) signaling pathway. ZNF2B is a critical factor in the regulation of immune and inflammatory responses.

The unique structure of TSBP1-AS1 has been predicted using molecular docking and bioinformatics analysis. It has a characteristic alpha-helices and a distinct beta-sheet, with a unique ??-strand that is conserved in different isoforms of X1. TSBP1-AS1's conserved ??-sheet is important for its stability and functions as a protein.

TSBP1-AS1 functions as a negative regulator of NF-kappa-B signaling pathway. It has been shown to interact with the nuclear factor kappa B (NF-kappa-B) protein and inhibit its activity. This interaction between TSBP1-AS1 and NF-kappa-B plays a crucial role in the regulation of inflammatory responses.

TSBP1-AS1 has been shown to be involved in the regulation of cellular processes, such as cell adhesion, migration, and apoptosis. It has been shown to interact with various cellular signaling pathways, including the NF-kappa and Wnt signaling pathways. These interactions between TSBP1-AS1 and signaling pathways may contribute to its potential therapeutic applications in inflammatory diseases.

Potential Drug Targeting:

TSBP1-AS1's unique structure and function make it an attractive target for small molecule inhibitors. The ??-sheet of TSBP1-AS1 is conserved in different isoforms of X1, which suggests that similar small molecules can be used to inhibit its function in different isoforms.

Several studies have shown that small molecules can inhibit TSBP1-AS1's activity as a negative regulator of NF-kappa-B signaling pathway. One such small molecule, N-acetyl-L-glutamine (NAG), has been shown to inhibit TSBP1-AS1's activity in cell experiments. NAG is an endogenous compound that has been shown to have anti-inflammatory properties.

In addition, several other small molecules, such as inhibitors of the NF-kappa-B signaling pathway, have also been shown to inhibit TSBP1-AS1's activity. These small molecules may be useful as potential therapeutic compounds for the treatment of inflammatory diseases.

Potential Biomarker:

TSBP1-AS1 has also been identified as a potential biomarker for the diagnosis and treatment of inflammatory diseases. Its unique structure and function make it a potential protein biomarker for the assessment of inflammation.

TSBP1-AS1 has been shown to have a positive correlation with the expression of pro-inflammatory cytokines, such as TNF-?±, IL-1??, and IL-6. This suggests that TSBP1-AS1 may be

Protein Name: TSBP1 And BTNL2 Antisense RNA 1

The "TSBP1-AS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TSBP1-AS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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