CENPL: A Key Regulator of T Cell Function and Disease (G91687)

Target Name: CENPL

NCBI ID: G91687

CENPL

CENPL: A Key Regulator of T Cell Function and Disease

CENPL (CENPL\\_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and kidneys. It is a key regulator of the hematopoietic system, which is responsible for the production and maintenance of blood cells.

CENPL is a member of the T-cell receptor (TCR) family, which is a group of proteins that play a critical role in the immune system. TCRs are composed of a constant region, which includes a transmembrane domain and a cytoplasmic tail, and a variable region, which includes several distinct domains that can interact with antigens.

CENPL is a 21-kDa protein that is expressed in the T cells, B cells, and natural killer cells. It is a critical regulator of the TCR, as it is involved in the negative regulation of TCR function. Specifically, CENPL is involved in the regulation of TCR clustering, which is the process by which T cells recognize antigens on the surface of target cells.

CENPL is also involved in the regulation of T cell activation and proliferation. It has been shown to play a critical role in the negative regulation of T cell activation, as well as in the regulation of T cell proliferation.

CENPL is a potential drug target, as it is thought to be involved in the regulation of several important cellular processes that are involved in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

CENPL is also a potential biomarker, as its levels can be easily measured and its expression can be used as a target for therapeutic intervention. For example, studies have shown that increasing the expression of CENPL has been associated with several benefits, including improved survival in cancer patients and regression of neurodegenerative diseases.

In conclusion, CENPL is a protein that is expressed in various tissues of the human body and is involved in the regulation of key cellular processes, including the hematopoietic system and T cell function. It is a potential drug target and biomarker, and further research is needed to fully understand its role in human health and disease.

Protein Name: Centromere Protein L

Functions: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex

The "CENPL Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CENPL comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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