Chromatin remodeling regulator CECR2: A drug target and biomarker

Target Name: CECR2

NCBI ID: G27443

CECR2

Chromatin remodeling regulator CECR2: A drug target and biomarker

Chromatin remodeling regulators are a class of enzymes that play a critical role in the regulation of chromatin structure and function. These enzymes are involved in the process of chromatin remodeling, which allows for the dynamic regulation of gene expression and the formation of distinct chromatin domains. CECR2, a gene that encodes a protein known as CRL2, is one of these enzymes.

CECR2 is a non-coding RNA molecule that plays a central role in the process of chromatin remodeling. It is a key regulator of the chromatin remodeling complex (RCC), which is a complex of proteins that work together to modify the chromatin structure and gene expression. The RCC includes the core subunits E1A, E2A, B2A, and B2B, as well as the peripheral subunits A, B, C, and D. CECR2 interacts with these subunits and is involved in the regulation of chromatin remodeling complex assembly, stability , and dynamics.

One of the key functions of CECR2 is its ability to regulate the assembly and disassembly of the RCC. This is accomplished through its interaction with the protein NEDD8, which is a negative regulator of the RCC. NEDD8 recognizes a specific sequence in the CECR2 protein and interacts with it to prevent its assembly with the RCC. This interaction between CECR2 and NEDD8 is critical for the regulation of chromatin remodeling complex stability and dynamics.

Another function of CECR2 is its role in the regulation of gene expression. CECR2 has been shown to interact with the protein p16, which is a negative regulator of gene expression. This interaction between CECR2 and p16 allows for the regulation of p16 stability and its ability to prevent the degradation of target genes. This function of CECR2 is important for the regulation of cellular processes such as cell growth, apoptosis, and stem cell maintenance.

In addition to its role in regulating the assembly and disassembly of the RCC and the regulation of gene expression, CECR2 is also involved in the regulation of DNA replication and repair. CECR2 has been shown to interact with the protein RPA1, which is involved in the regulation of DNA replication and repair. This interaction between CECR2 and RPA1 allows for the regulation of RPA1 stability and its ability to prevent the degradation of target genes.

CECR2 has also been shown to play a role in the regulation of cellular signaling pathways. For example, CECR2 has been shown to interact with the protein CSN5, which is involved in the regulation of DNA-protein binding and gene expression. This interaction between CECR2 and CSN5 allows for the regulation of CSN5 stability and its ability to promote the association of DNA with the protein CSN5.

Despite its involvement in several important cellular processes, CECR2 is still an poorly understood protein. little is known about its structure, function, and the specific ways in which it interacts with other proteins. This lack of understanding makes it difficult to use CECR2 as a drug target or biomarker. However, studies have shown that CECR2 is involved in several cellular processes and its dysfunction may have implications for a variety of diseases.

In conclusion, CECR2 is a non-coding RNA molecule that plays a critical role in the regulation of chromatin structure and function. Its ability to regulate the assembly and disassembly of the RCC, the regulation of gene expression, DNA replication and repair, and cellular signaling pathways make it an attractive drug target and biomarker. Further studies are needed to fully understand the function of CECR2 and its potential implications for diseases.

Protein Name: CECR2 Histone Acetyl-lysine Reader

Functions: Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:15640247, PubMed:26365797, PubMed:28801535, PubMed:22464331). The complexes do not have the ability to slide mononucleosomes to the center of a DNA template (PubMed:28801535). The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex (PubMed:28801535). Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity). In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331). May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465)

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