CENPI: A Potential Drug Target and Biomarker for Centromere Complex Protein 19

Target Name: CENPI

NCBI ID: G2491

CENPI

CENPI: A Potential Drug Target and Biomarker for Centromere Complex Protein 19

Centromere complex (CENP) proteins play a crucial role in the proper functioning of the mitotic spindle, which is essential for cell division. CENP proteins help to ensure the proper organization and stability of the spindle, as well as the proper transfer of genetic information during the cell cycle. One of the CENP proteins, CENPI (interphase centromere complex protein 19), has been identified as a potential drug target and biomarker for several reasons.

Properties of CENPI

CENPI is a 21-kDa protein that is expressed in a variety of tissues, including brain, heart, and muscle. It is highly homogeneous and has a calculated pI of 6.97. CENPI is a member of the centromere complex, which is a protein complex that is essential for the proper functioning of the mitotic spindle. This complex includes several proteins that help to ensure the stability and organization of the spindle.

Function of CENPI

CENPI is involved in several important functions of the centromere complex. First, it helps to ensure the proper stability of the spindle. CENPI has been shown to interact with several other proteins in the CENP complex, including cofilin and the protein network that is involved in the organization of the spindle. Second, CENPI is involved in the regulation of the level of mitotic spindle stability. This is done by its ability to interact with the protein kinesin-2, which is involved in the regulation of the level of microtubules in the spindle.

Drug Targeting and Biomarker

The potential drug targeting of CENPI is based on its involvement in the centromere complex and its ability to interact with several proteins that are involved in this complex. CENPI has been shown to play a role in the regulation of the stability and organization of the spindle, which is critical for the proper functioning of the cell.

One of the potential drug targets for CENPI is the inhibition of microtubule dynamics, which is done by drugs that are able to disrupt the interaction between CENPI and kinesin-2. This would result in a decrease in the stability and organization of the spindle, which would be expected to have a negative impact on the proper functioning of the cell.

Another potential drug target for CENPI is the inhibition of the activity of cofilin, which is a protein that is involved in the regulation of the level of microtubules in the spindle. Cenapin, a drug that is currently in clinical trials for the treatment of multiple sclerosis, is an inhibitor of cofilin and has been shown to interact with CENPI. This interaction would be expected to result in a decrease in the stability and organization of the spindle, which would be expected to have a negative impact on the proper functioning of the cell.

Biomarker

CENPI has also been identified as a potential biomarker for several reasons. First, its expression is highly sensitive to several variables, including temperature and pH, which makes it a stable and reliable biomarker. Second, CENPI has been shown to have a similar distribution to other CENP proteins, which suggests that it is a reliable biomarker for the CENP complex.

Conclusion

In conclusion, CENPI is a protein that is involved in several important functions of the centromere complex. Its involvement in these functions makes it a potential drug target and biomarker. The inhibition of microtubule dynamics and the inhibition of the activity of cofilin are two potential drug targets for CENPI. Further research is needed to determine the exact mechanisms of CENPI's involvement in the

Protein Name: Centromere Protein I

Functions: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone

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