CENPT: A Protein with Potential as A Drug Target (G80152)

Target Name: CENPT

NCBI ID: G80152

CENPT

CENPT: A Protein with Potential as A Drug Target

CENPT (CPTN) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key player in the regulation of blood pressure and has been linked to a number of health conditions, including heart disease, diabetes, and neurodegenerative diseases.

Recent studies have identified CENPT as a potential drug target for a number of diseases, including hypertension, heart failure, and neurodegenerative disorders. Its unique structure and regulation by multiple signaling pathways make it an attractive target for drug development.

One of the key challenges in developing new drugs is the development of resistance to these drugs, which can limit their effectiveness and increase the risk of side effects. However, CENPT has been shown to be a stable and druggable target, with several studies indicating that it is responsive to a range of drug treatments.

One of the key mechanisms by which CENPT is regulated is through the production of dihydroptidylamine (DHPA), which is a key intracellular signaling molecule. DHPA is produced by the breakdown of a food compound called choline, which is found in a variety of plant and animal sources, including eggs, beans, and meat.

CENPT is a key regulator of DHPA synthesis and has been shown to play a role in the regulation of various physiological processes, including blood pressure, inflammation, and neurodegeneration. Studies have shown that changes in CENPT levels or activity can have a significant impact on the levels of DHPA in cells, and these changes can be associated with a range of different physiological and pathological processes.

In addition to its role in DHPA synthesis, CENPT is also involved in the regulation of several other signaling pathways that are important for maintaining cellular homeostasis. These include the regulation of ion channels, the production of reactive oxygen species (ROS), and the regulation of protein synthesis.

CENPT has also been shown to play a role in the regulation of cellular processes that are important for maintaining tissue structure and homeostasis. For example, it has been shown to be involved in the regulation of cell proliferation, migration, and the formation of blood vessels.

Given its involvement in a range of important cellular processes, CENPT is an attractive target for drug development. Several studies have shown that CENPT is responsive to a range of drug treatments, including inhibitors of its synthesis, modulators of its activity, and antibodies that target its surface.

In addition to its potential as a drug target, CENPT is also a potential biomarker for a number of diseases. Its regulation by multiple signaling pathways makes it an attractive target for study, and its decreased expression in the brains of individuals with hypertension has been shown to be associated with an increased risk of cognitive impairment and other neurological disorders.

Overall, CENPT is a protein that has the potential to be a drug target for a number of diseases, including hypertension, heart failure, and neurodegenerative disorders. Its unique structure and regulation by multiple signaling pathways make it an attractive target for drug development, and its potential as a biomarker for these diseases makes it an important area of 鈥嬧?媠tudy.

While the development of new drugs can be a complex and time-consuming process, the identification of potential targets like CENPT is an important step in this process. Further research is needed to fully understand the role of CENPT in these diseases and to develop effective treatments .

Protein Name: Centromere Protein T

Functions: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis

The "CENPT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CENPT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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