Understanding The Role of CENPP in Human Disease (G401541)

Target Name: CENPP

NCBI ID: G401541

CENPP

Understanding The Role of CENPP in Human Disease

CENPP, or Centromere protein P (isoform a), is a protein that is expressed in most tissues of the body, including muscle, nerve, and heart cells. It is a key component of the centromere region of chromosomes, which plays a critical role in the proper formation of chromosomes during cell division.

CENPP is made up of four distinct isoforms, which are produced by alternative splicing of the gene that encodes it. These isoforms are: P1, P2, P3, and P4. P1 is the most abundant isoform, and it is the one that is primarily involved in chromosome stability and replication. P2 and P3 isoforms are less abundant, and they are involved in the regulation of gene expression. P4 is the least abundant isoform, and it is involved in the regulation of DNA replication and repair.

CENPP is a protein that has been studied extensively in the context of human disease, and it has been identified as a potential drug target and biomarker. One of the main reasons for this is the fact that changes in the levels of CENPP can be associated with the development of a wide range of diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the key functions of CENPP is its role in the regulation of gene expression. CENPP can interact with various transcription factors, including RNA polymerase II, to regulate the expression of genes. This interaction between CENPP and transcription factors makes it an attractive target for drugs that are designed to interfere with the activity of these transcription factors.

In addition to its role in gene expression, CENPP is also involved in the regulation of chromosome stability and replication. It plays a key role in ensuring that chromosomes are properly replicated and that they are stable during the process of cell division. This is important because changes in the levels of CENPP can be associated with the development of chromosomal abnormalities, which can lead to a wide range of diseases, including Down syndrome and leukemia.

Another potential mechanism by which CENPP may be involved in the development of disease is its role in the regulation of cellular signaling pathways. CENPP has been shown to play a key role in the regulation of theNotch signaling pathway, which is involved in the regulation of cell proliferation and survival. This is important because changes in the levels of CENPP can be associated with the development of various diseases, including cancer.

In addition to its role in the regulation of cellular signaling pathways, CENPP is also involved in the regulation of inflammation. It has been shown to play a key role in the regulation of the NF-kappa-B signaling pathway, which is involved in the regulation of inflammation and immune responses. This is important because changes in the levels of CENPP can be associated with the development of various inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.

Overall, CENPP is a protein that has been studied extensively in the context of human disease, and it has potential as a drug target and biomarker. Its role in the regulation of gene expression, chromosome stability, and replication, as well as its involvement in the regulation of cellular signaling pathways and inflammation, makes it an attractive target for drugs that are designed to interfere with its activity. Further research is needed to fully understand the role of CENPP in human disease, and to develop effective treatments based on this understanding.

Protein Name: Centromere Protein P

Functions: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex

The "CENPP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CENPP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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