CENPQ: A Potential Drug Target and Biomarker forCentromere Protein Q

Target Name: CENPQ

NCBI ID: G55166

CENPQ

Other Name(s): Centromere protein Q | CENPQ_HUMAN | CENP-Q | C6orf139 | centromere protein Q

CENPQ: A Potential Drug Target and Biomarker forCentromere Protein Q

Chromatin is the double helix of DNA and RNA, and it plays a crucial role in the regulation of gene expression. The centromere region of a chromosome is a special region that is responsible for the proper assembly and retention of chromosomes during cell division. The centromere protein Q (CENPQ) is a key protein that is expressed in the centromere region of chromosomes and is involved in the regulation of chromosome structure and function.

CENPQ is a 21-kDa protein that is composed of 195 amino acid residues. It has a molecular weight of 21 kDa and a calculated pI of 9.65. CENPQ is expressed in all eukaryotic cells and is highly conserved across different species. It is also known as TAF100 and has been identified as a potential drug target and biomarker.

Drug Target Potential

CENPQ is a protein that is involved in the regulation of several cellular processes, including DNA replication, transcription, and histone modifications. It is a key regulator of microRNA (miRNA) expression, which are small non-coding RNAs that play a crucial role in post-transcriptional gene regulation. CENPQ has been shown to interact with miRNA-21 (miR-21), a negative regulator of SIRT1, which is a DNA damage repair enzyme.

CENPQ has also been shown to interact with the transcription factor, p53. p53 is a well-known protein that is involved in the regulation of DNA replication and repair. CENPQ has been shown to play a role in the regulation of p53 function, which may include the inhibition of its activity.

Biomarker Potential

CENPQ has also been shown to be a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. One of the potential mechanisms by which CENPQ may be involved in the development of cancer is its role in the regulation of miRNA expression. Cancer cells often have increased levels of miRNA expression, which can contribute to the development of a cancer-promoting environment.

CENPQ has also been shown to be involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and may be caused by the accumulation of damaged proteins, including misfolded proteins. CENPQ has been shown to play a role in the regulation of the aggregation and retention of misfolded proteins, which may contribute to the development of neurodegenerative diseases.

CENPQ has also been shown to be involved in the regulation of psychiatric disorders, including depression and anxiety. These conditions are characterized by the presence of disruptions in the regulation of brain chemistry, including changes in the levels of neurotransmitters, such as dopamine. CENPQ has been shown to play a role in the regulation of neurotransmitter release and the modulation of brain activity, which may contribute to the development of psychiatric disorders.

Conclusion

In conclusion, CENPQ is a protein that is involved in the regulation of several cellular processes, including DNA replication, transcription, and histone modifications. It is a potential drug target and biomarker for several diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. Further research is needed to fully understand the role of CENPQ in these conditions and to develop effective treatments.

Protein Name: Centromere Protein Q

Functions: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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