HIBM: A Protein Involved in Metabolism and Cell Regulation (G11112)

Target Name: HIBADH

NCBI ID: G11112

HIBADH

HIBM: A Protein Involved in Metabolism and Cell Regulation

HIBM (3-hydroxyisobutyrate dehydrogenase) is a protein that is expressed in various tissues throughout the body, including the liver, muscle, and heart. It is a key enzyme in the metabolism of isobutyrate, a molecule that is involved in the production of energy in the body.

One of the unique features of HIBM is its structure. It is a transmembrane protein that spans the entire width of the cell membrane, and it is held in place by its extracellular domain. This allows it to interact with various cellular components on the same side of the membrane, which is important for its function in metabolism.

HIBM is involved in a number of different metabolic pathways. For example, it is involved in the citric acid cycle, which is the process by which the body produces energy from the food we eat. In this pathway, HIBM helps to convert the isobutyrate molecule into the more energy-rich form of succinyl-CoA.

Another important function of HIBM is its role in the production of the amino acid leucine. Leucine is an important protein that is involved in muscle growth and repair, as well as the production of hormones and other signaling molecules. HIBM is also involved in the metabolism of other amino acids, including glutamine and aspartic acid.

In addition to its role in metabolism, HIBM is also involved in the regulation of cellular processes. For example, it has been shown to play a role in the regulation of cell death, as well as the control of cell proliferation.

Despite its importance in various cellular processes, HIBM is not yet a well-studied protein. There are only a few studies that have investigated its function in metabolism and cellular regulation. However, these studies have identified some important insights into the biology of HIBM.

One of the most promising aspects of HIBM is its potential as a drug target. The ability of HIBM to interact with various cellular components on the same side of the membrane makes it an attractive target for small molecules that can modulate its activity. Additionally, HIBM is involved in the production of important molecules such as succinyl-CoA, which could make it an attractive target for drugs that are designed to promote the production of this molecule.

Another potential mechanism by which HIBM could be targeted by drugs is its role in the regulation of cell death. The ability of HIBM to regulate cell death by controlling the production of pro-apoptotic proteins suggests that it may be a useful target for drugs that are designed to induce or inhibit cell death.

In conclusion, HIBM is a protein that is involved in a number of different cellular processes, including metabolism and cell regulation. Its unique structure, which allows it to interact with various cellular components on the same side of the membrane, makes it an attractive target for small molecules that can modulate its activity. Additionally, HIBM's role in the production of important molecules such as succinyl-CoA and its involvement in the regulation of cell death make it an attractive target for drugs that are designed to promote or inhibit these processes. Further research is needed to fully understand the biology of HIBM and its potential as a drug target.

Protein Name: 3-hydroxyisobutyrate Dehydrogenase

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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