Unlocking the Potential of TNFRSF13C as a Drug Target and Biomarker

Target Name: TNFRSF13C

NCBI ID: G115650

TNFRSF13C

Unlocking the Potential of TNFRSF13C as a Drug Target and Biomarker

The tumor necrosis factor-related superfamily (TNFSF) is a diverse family of cytokines and cytoskeletal components that play a crucial role in various cellular processes, including inflammation and cell survival. The TNFRSF13C member is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer.

Overview of TNFRSF13C

TNFRSF13C is a 21-kDa transmembrane protein that is expressed in various tissues, including the brain, spleen, and Peyer's patches of the intestine. It is a key member of the TNFRSF13 family, which includes four other proteins: TNFRSF13A, TNFRSF13B, TNFRSF13D, and TNFRSF13E. These proteins are involved in the regulation of cellular responses to stress and damage, including inflammation and stress-induced programmed cell death.

TNFRSF13C functions as a receptor for the cytokine TGF-β, which is a key mediator of cellular stress and damage. TGF-β is a potent motivator of cell proliferation, differentiation, and survival, and it has been implicated in the development and progression of many diseases, including cancer. The activity of TGF-β has been linked to the regulation of various cellular processes, including cell adhesion, migration, and survival.

TNFRSF13C is involved in the regulation of TGF-β signaling by several mechanisms. Firstly, it functions as a negative regulator of TGF-β signaling, which means that it limits the activity of TGF-β and inhibits its effects on cell signaling pathways. Secondly, it is a critical component of the TGF-β signaling pathway, as it facilitates the interaction between TGF-β and its downstream targets.

TNFRSF13C has been shown to play a crucial role in the regulation of cellular responses to various stressors, including ionizing radiation, chemotherapy, and infection. It has been shown to enhance the sensitivity of cancer cells to these stressors and to inhibit their ability to survive the stress-induced cell death.

In addition to its role in TGF-β signaling, TNFRSF13C has also been shown to play a role in the regulation of cellular adhesion and migration. It is involved in the formation of tight junctions, which are a type of cell-cell adhesion structure that helps to maintain tissue integrity and prevent excessive fluid leakage. It is also involved in the regulation of cell migration, which is critical for the development of new tissues and organs during development and growth.

Drug Targeting and Biomarker Potential

The potential drug targeting of TNFRSF13C is due to its involvement in TGF-β signaling and its role in the regulation of cellular stress and damage. Several studies have shown that inhibitors of TGF-β signaling, such as inhibitors of the FGF-1 receptor or the SMAD inhibitor, can enhance the sensitivity of cancer cells to chemotherapy and radiation.

Furthermore, the ability of TNFRSF13C to regulate TGF-β signaling has also been used as a biomarker for the diagnosis and prognosis of various diseases, including cancer. For example, it has been shown that TNFRSF13C levels are elevated in various types of cancer, including breast, ovarian, and prostate cancer. Additionally, studies have shown that inhibitors of TGF-β signaling have been effective in preclinical models of cancer, including the inhibition of TGF-β signaling has led to the regression of established cancer tumors.

Conclusion

TNFRSF13C is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its involvement in TGF-β signaling and its role in the regulation of cellular stress and damage make it an attractive target for

Protein Name: TNF Receptor Superfamily Member 13C

Functions: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response

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