STAT4: Signal Transducer and Activator of Transcription 4 (G6775)

Target Name: STAT4

NCBI ID: G6775

STAT4

STAT4: Signal Transducer and Activator of Transcription 4

STAT4, or Signal Transducer and Activator of Transcription 4, is a protein that plays a crucial role in cell signaling. It is a key transcription factor that regulates the expression of genes in the cell, and is often involved in the regulation of cell growth, differentiation, and survival.

STAT4 is a cytoplasmic protein that is primarily located in the cytoplasm of cells. It is a member of the signal transducer and activator of transcription (STA) family, which includes several other proteins that play a similar role in regulating gene expression.

One of the key functions of STAT4 is its role as a transcription factor. It is able to bind to specific DNA sequences and activate the expression of genes that are located within those sequences. This allows it to regulate the production of proteins that are essential for cell growth and survival.

STAT4 is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and response to stimuli. It is also involved in the regulation of cell survival, and is often activated when the cell is facing the risk of death or damage.

In addition to its role as a transcription factor, STAT4 is also involved in the regulation of cellular signaling pathways. It is a key player in the regulation of the transforming growth factor (TGF-1) signaling pathway, and is often involved in the regulation of TGF-1-induced cell growth and differentiation.

STAT4 is also involved in the regulation of inflammation, and is often activated when the body is responding to an infection or inflammation. This allows it to play a role in the regulation of the immune response and the production of antibodies.

In conclusion, STAT4 is a protein that plays a crucial role in cell signaling. It is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and response to stimuli. It is also involved in the regulation of cellular signaling pathways and in the regulation of inflammation. As a result, it is a potential drug target and biomarker for a variety of diseases.

Protein Name: Signal Transducer And Activator Of Transcription 4

Functions: Transcriptional regulator mainly expressed in hematopoietic cells that plays a critical role in cellular growth, differentiation and immune response (PubMed:8943379, PubMed:10961885). Plays a key role in the differentiation of T-helper 1 cells and the production of interferon-gamma (PubMed:12213961, PubMed:35614130). Participates also in multiple neutrophil functions including chemotaxis and production of the neutrophil extracellular traps (By similarity). After IL12 binding to its receptor IL12RB2, STAT4 interacts with the intracellular domain of IL12RB2 and becomes tyrosine phosphorylated (PubMed:7638186, PubMed:10415122). Phosphorylated STAT4 then homodimerizes and migrates to the nucleus where it can recognize STAT target sequences present in IL12 responsive genes. Although IL12 appears to be the predominant activating signal, STAT4 can also be phosphorylated and activated in response to IFN-gamma stimulation via JAK1 and TYK2 and in response to different interleukins including IL23, IL2 and IL35 (PubMed:11114383, PubMed:34508746). Transcription activation of IFN-gamma gene is mediated by interaction with JUN that forms a complex that efficiently interacts with the AP-1-related sequence of the IFN-gamma promoter (By similarity). In response to IFN-alpha/beta signaling, acts as a transcriptional repressor and suppresses IL5 and IL13 mRNA expression during response to T-cell receptor (TCR) activation (PubMed:26990433)

The "STAT4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about STAT4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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