STARD9: A Protein Involved in Lipid Metabolism and Disease Development

Target Name: STARD9

NCBI ID: G57519

STARD9

STARD9: A Protein Involved in Lipid Metabolism and Disease Development

The STARD9 protein, also known as START domain containing 9, is a protein that is found in the endoplasmic reticulum (ER) and is involved in the transport of lipids across the membrane of cells. Lipids are an essential component of all cells and are used for various functions, including energy storage, insulation, and cell membrane structure. The transport of lipids across the membrane is a critical process that is regulated by a variety of proteins, including STARD9.

The STARD9 protein is composed of 9 subunits that are held together by non-covalent interactions. The subunits include a N-terminal domain, a transmembrane domain, and a C-terminal domain. The N-terminal domain contains a nucleotide-binding oligomerization (NBO) domain that is responsible for binding to various nucleotides. The transmembrane domain is responsible for the protein's ability to pass through the membrane and for its stability. The C-terminal domain contains a leucine-rich repeat (LRR) domain that is involved in the protein's stability and functions as a scaffold.

STARD9 is a protein that has been identified as a potential drug target in various diseases, including heart disease, diabetes, and cancer. Its involvement in the transport of lipids across the membrane makes it a promising target for treatments that target lipid metabolism.

One of the main mechanisms by which STARD9 is involved in lipid metabolism is its role in the transport of free fatty acids (FFAs) across the membrane. FFA are molecules that are produced by our bodies and are essential for energy metabolism. However, if they become out of balance, they can contribute to the development of diseases such as heart disease and cancer. STARD9 is involved in the transport of FFA across the membrane, which helps to maintain a balance of FFAs and keeps them out of the bloodstream.

In addition to its role in lipid metabolism, STARD9 is also involved in the regulation of cellular signaling pathways. Its NBO domain is known to interact with various nucleotides, including GTP and CTP, which are involved in intracellular signaling. This suggests that STARD9 may be involved in regulating cellular signaling pathways and is a potential drug target for diseases that are characterized by abnormal cellular signaling.

The STARD9 protein has also been shown to play a role in the regulation of cellular processes that are important for the development and progression of diseases. For example, studies have shown that STARD9 is involved in the regulation of cellular senescence, which is the process by which cells begin to deteriorate and are no longer able to divide. This suggests that STARD9 may be a potential drug target for diseases that are characterized by cellular senescence.

Another potential mechanism by which STARD9 is involved in disease development is its role in the regulation of inflammation. The C-terminal domain of STARD9 contains a leucine-rich repeat (LRR) domain that is known to be involved in the regulation of inflammation. This suggests that STARD9 may be involved in the regulation of inflammation and is a potential drug target for diseases that are characterized by inflammation.

In conclusion, the STARD9 protein is a protein that is involved in the transport of lipids across the membrane of cells. Its involvement in lipid metabolism, cellular signaling pathways, and inflammation makes it a potential drug target for diseases that are characterized by abnormal cellular processes. Further research is needed to fully understand the role of STARD9 in disease development and to develop effective treatments.

Protein Name: StAR Related Lipid Transfer Domain Containing 9

Functions: Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM)

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