Discovering The Potential of STARD3: A Protein Involved in Cell Signaling and Cancer

Target Name: STARD3

NCBI ID: G10948

STARD3

Discovering The Potential of STARD3: A Protein Involved in Cell Signaling and Cancer

STARD3 (Metastatic Lymph Node Gene 64 Protein) is a protein that is expressed in various tissues, including lymph nodes, and is involved in cell signaling processes. It has been identified as a potential drug target and biomarker for various diseases, including cancer. In this article, we will discuss the biology of STARD3, its potential as a drug target, and its potential as a biomarker for various diseases.

Structure and Function

STARD3 is a 64kDa protein that is expressed in various tissues, including lymph nodes, bone marrow, and various organs. It has a molecular weight of 72 kDa and a calculated pI of 6.9. STARD3 is a member of the TAD family, which includes proteins that are involved in cell signaling processes.

STARD3 is involved in various signaling pathways, including the TGF-β pathway and the NF-kappa-B pathway. The TGF-β pathway is involved in cell growth, differentiation, and survival, while the NF-kappa-B pathway is involved in inflammation and cellular signaling. STARD3 is involved in these pathways by regulating various signaling pathways, including the TGF-β pathway, which is involved in cell signaling processes, and the NF-kappa-B pathway, which is involved in inflammation and cellular signaling.

Potential as a Drug Target

STARD3 has been identified as a potential drug target for various diseases, including cancer. Its involvement in the TGF-β pathway and the NF-kappa-B pathway makes it an attractive target for drugs that are designed to inhibit these pathways. For example, inhibitors of the TGF-β pathway have been shown to be effective in treating various types of cancer, including breast, ovarian, and prostate cancers. In addition, inhibitors of the NF-kappa-B pathway have also been shown to be effective in treating various types of cancer.

Potential as a Biomarker

STARD3 has also been identified as a potential biomarker for various diseases, including cancer. Its involvement in the TGF-β pathway and the NF-kappa-B pathway makes it an attractive target for biomarkers that can be used to diagnose and monitor the effectiveness of cancer treatments. For example, levels of STARD3 have been shown to be elevated in various types of cancer, including breast, ovarian, and prostate cancers. This suggests that STARD3 may be a useful biomarker for these diseases.

Conclusion

In conclusion, STARD3 is a protein that is involved in cell signaling processes and has been identified as a potential drug target and biomarker for various diseases, including cancer. Its involvement in the TGF-β pathway and the NF-kappa-B pathway makes it an attractive target for drugs that are designed to inhibit these pathways. Additionally, its potential as a biomarker for various diseases makes it an attractive target for diagnostic and monitoring purposes. Further research is needed to fully understand the biology of STARD3 and its potential as a drug target and biomarker.

Protein Name: StAR Related Lipid Transfer Domain Containing 3

Functions: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263, PubMed:28377464). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (PubMed:28377464). May also mediate cholesterol transport between other membranes, such as mitochondria membrane or cell membrane (PubMed:12070139, PubMed:19965586). However, such results need additional experimental evidences; probably mainly mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:28377464). Does not activate transcriptional cholesterol sensing (PubMed:28377464). Able to bind other lipids, such as lutein, a xanthophyll carotenoids that form the macular pigment of the retina (PubMed:21322544)

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