STAC3: A Potential Drug Target Or Biomarker for Cancer and Neurodegenerative Diseases

Target Name: STAC3

NCBI ID: G246329

STAC3

STAC3: A Potential Drug Target Or Biomarker for Cancer and Neurodegenerative Diseases

STAC3 (Sterile-Transport Stress Response Protein-3) is a protein that is expressed in various cell types, including epithelial and endothelial cells, and plays a crucial role in cell signaling and inflammation. It is a key regulator of the TGF-β pathway , which is a well-known pathway that regulates cell growth, differentiation, and survival. STAC3 has also been shown to be involved in several cellular processes, including cell adhesion, migration, and the regulation of inflammation.

Recent studies have suggested that STAC3 may have potential as a drug target or biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One potential mechanism by which STAC3 may be involved in cancer is its role in cell adhesion and migration. Studies have shown that STAC3 plays a role in the regulation of cell-cell adhesion by promoting the interaction between its extracellular domain and the cytoskeleton. This interaction allows STAC3 to regulate the movement of cells along the body's surface, which is critical for various physiological processes, including embryonic development and tissue repair.

In addition, STAC3 has also been shown to be involved in the regulation of cell migration. Studies have shown that STAC3 plays a role in the production of the protein PDGFR-尾, which is a key regulator of cell migration. This interaction between STAC3 and PDGFR -尾 suggests that STAC3 may be a potential drug target or biomarker for cancer, as inhibition of this interaction may be a useful way to treat cancer.

Another potential mechanism by which STAC3 may be involved in neurodegenerative diseases is its role in the regulation of inflammation. Studies have shown that STAC3 plays a key role in the regulation of inflammation by promoting the production of pro-inflammatory cytokines. This interaction between STAC3 and pro -inflammatory cytokines suggest that STAC3 may be a potential drug target or biomarker for neurodegenerative diseases, as inhibition of this interaction may be a useful way to treat these conditions.

In addition, STAC3 has also been shown to be involved in the regulation of cellular processes that are important for brain development and function. For example, STAC3 has been shown to play a role in the regulation of neuron growth and differentiation, as well as the regulation of synaptic plasticity. These interactions between STAC3 and neuron growth, differentiation, and synaptic plasticity suggest that STAC3 may be a potential drug target or biomarker for neurodegenerative diseases.

In conclusion, STAC3 is a protein that has been shown to play a crucial role in several cellular processes that are important for various physiological functions, including cell adhesion, migration, and inflammation. These interactions suggest that STAC3 may be a potential drug target or biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of STAC3 in these processes and to develop effective treatments.

Protein Name: SH3 And Cysteine Rich Domain 3

Functions: Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels (PubMed:23736855, PubMed:29078335). Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane (By similarity). Slows down the inactivation rate of the calcium channel CACNA1C (PubMed:29078335)

The "STAC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about STAC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets