Unlocking the Potential of ST8SIA5: A Drug Target and Biomarker for Alpha-2,8-SialylTransferase 5

Target Name: ST8SIA5

NCBI ID: G29906

ST8SIA5

Unlocking the Potential of ST8SIA5: A Drug Target and Biomarker for Alpha-2,8-SialylTransferase 5

Introduction

Alpha-2,8-sialyltransferase 5 (ST8SIA5) is a protein that plays a crucial role in the development and maintenance of the tight junction network that tightly adheres to tissue cell membranes. Mutations in the ST8SIA5 gene can cause congenital neural tube malformations such as spina bifida, suggesting that ST8SIA5 plays a key role in neural development and maintaining the stability of tissue structure. However, current research on ST8SIA5 mainly focuses on the relationship between ST8SIA5 gene mutations and spina bifida and the role of ST8SIA5 in neurodevelopment. This article aims to explore the potential role of ST8SIA5 in drug research and clinical applications, and to reveal its application prospects in the biomedical field.

The relationship between ST8SIA5 gene and spina bifida

Spina bifida is a severe congenital neural tube malformation that usually occurs during embryonic life. This malformation causes destruction of the spinal cord and peripheral nerves, affecting the patient's neurological function and quality of life. Existing studies have found a significant association between ST8SIA5 gene mutations and spina bifida.

ST8SIA5 gene mutations can lead to narrowing of the neural tube lumen, blocking cell signaling. In addition, the ST8SIA5 gene mutation will also affect the stability of the tight junction network, making it difficult for tight junctions to form between cells, resulting in reduced information transmission between cells. These functional abnormalities lead to neural tube defects, which increase the risk of spina bifida.

The role of ST8SIA5 in neurodevelopment

ST8SIA5 plays multiple roles in neurodevelopment. First, the protein encoded by the ST8SIA5 gene is an extracellular matrix protein that plays an important role on the postsynaptic membrane between neuronal cells. These extracellular matrix proteins are in close contact with neuronal cell membranes and provide the physical basis for signal transmission between neurons.

In addition, the protein encoded by the ST8SIA5 gene is also involved in regulating the neuronal cell cycle and promoting the proliferation and sorting of neuronal cells. This process helps maintain the diversity of neuronal cell functions, enabling information transmission and coordination in neural networks.

Potential role of ST8SIA5 in drug research and clinical applications

With in-depth research on ST8SIA5, people have discovered the potential role of ST8SIA5 in drug research and clinical applications. First, ST8SIA5 may become a new target for the treatment of neural tube malformations such as spina bifida. Drug treatment targeting the ST8SIA5 gene is expected to improve the neurological function and quality of life of patients with neural tube defects.

In addition, ST8SIA5 may also become an important biomarker. By detecting the expression level of the ST8SIA5 gene, the recovery of neural tube defects in patients can be evaluated and personalized treatment plans can be provided for patients.

in conclusion

There is a significant association between ST8SIA5 gene mutations and spina bifida. ST8SIA5 plays a key role in neural development and maintaining the stability of tissue structure. With the deepening of research on ST8SIA5, the potential role of ST8SIA5 in drug research and clinical application has become increasingly apparent. By further exploring the functions of ST8SIA5 in neural development and signal transmission, it is expected to provide new ideas and methods for the treatment of neural tube malformations such as spina bifida.

Protein Name: ST8 Alpha-N-acetyl-neuraminide Alpha-2,8-sialyltransferase 5

Functions: Involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, GP1c and GT3 from GD1a, GT1b, GM1b and GD3 respectively

The "ST8SIA5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ST8SIA5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets