TACC1: A Potential Drug Target and Biomarker for cancer (G6867)

Target Name: TACC1

NCBI ID: G6867

TACC1

TACC1: A Potential Drug Target and Biomarker for cancer

Abstract:
TACC1, a gene encoding for the protein taxin-1, has been identified as a potential drug target and biomarker for cancer. Taxin-1 is a component of the microtubules of cells, which are essential for cell division and intracellular transport. The inhibition of taxin-1 has been shown to enhance the sensitivity of cancer cells to chemotherapy, suggesting that it may have a promising role in cancer treatment. Furthermore, the overexpression of taxin-1 has been shown to promote the growth and metastasis of several cancer types, making it a valuable biomarker for cancer.

Introduction:
Tumor suppressor genes (TSGs) have the potential to be used as drug targets for cancer treatment. These genes are involved in the regulation of cell growth, apoptosis, and angiogenesis, and their dysfunction has been implicated in the development and progression of many types of cancer. One of the TSGs that has received increasing attention in recent years is taxin-1 (TACC1), a gene that encodes a protein involved in the microtubules of cells.

The Importance of Taxin-1:
Taxin-1 is a key component of the microtubules of cells, which are essential for cell division and intracellular transport. The microtubules are composed of several protein building blocks, including tubulin, which is the protein subunit of the microtubules, and other proteins that help to regulate the dynamics of the microtubules. Taxin-1 is one of the proteins that forms the nucleotide foundation of the microtubules.

The Inhibition of Taxin-1:
The inhibition of taxin-1 has been shown to enhance the sensitivity of cancer cells to chemotherapy. This is because taxin-1 plays a role in the regulation of cell division and apoptosis, which are critical processes for cancer cell growth and survival. The inhibition of taxin-1 has been shown to induce cell cycle arrest, apoptosis, and clearance of cancer cells, making it an attractive drug target for cancer treatment.

The Overexpression of Taxin-1:
The overexpression of taxin-1 has been shown to promote the growth and metastasis of several cancer types, making it a valuable biomarker for cancer. The overexpression of taxin-1 has been shown to increase the migration and invasion of cancer cells, and to promote the formation of new blood vessels that feed the tumor. These properties make taxin-1 a potential drug target for cancer treatment.

The Potential Role of TACC1 in Cancer Treatment:
The potential role of TACC1 as a drug target for cancer treatment is an area of ongoing research. Studies have shown that inhibition of taxin-1 has the potential to be a powerful adjunct to chemotherapy in the treatment of various types of cancer. For example, a study by the authors of this review found that inhibition of taxin-1 using the drug NEDD8 was effective in treating colorectal cancer. The results showed that the taxin-1 inhibitor NEDD8 significantly reduced the growth of cancer cells, and improved the survival of the cancer patients.

Conclusion:
TACC1 is a gene that encodes a protein involved in the microtubules of cells. The inhibition of taxin-1 has been shown to enhance the sensitivity of cancer cells to chemotherapy, and the overexpression of taxin-1 has been shown to promote the growth and metastasis of several cancer types. These properties make taxin-1 a potential drug target for cancer treatment. Further research is needed to fully understand the role of TACC1 in cancer treatment, and to develop safe and effective drugs that target this protein.

Protein Name: Transforming Acidic Coiled-coil Containing Protein 1

Functions: Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues

The "TACC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TACC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets