TACR2: The Neurokinin A Receptor: A Promising Drug Target and Biomarker

Target Name: TACR2

NCBI ID: G6865

TACR2

TACR2: The Neurokinin A Receptor: A Promising Drug Target and Biomarker

Introduction

The neurokinin A (Neurokinin A, NKA) receptor is a G protein-coupled receptor that plays a crucial role in neural circuits and signaling. It is one of the most abundant G protein-coupled receptors in the central nervous system (CNS), and Its activation is involved in a wide range of physiological processes, including pain modulation, anxiety, and neurotransmitter release. TACR2, a specific NKA receptor, has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders.

The NKA receptor is a family of G protein-coupled receptors that consists of four subunits: NKAR1, NKAR2, NKAR3, and NKAR4. These subunits differ in their thermal properties, intracellular location, ligand binding specificity, and signal transduction pathways. NKAR2 is TACR2, which is located on the postganglionic membrane. It is the largest NKAR and plays an important role in regulating the activity of the autonomic nervous system and participating in pain perception.

The role of TACR2

TACR2 plays an important role in the nervous system. Studies have shown that activation of TACR2 can cause an increase in neuronal action potentials and strengthen the connection between neurons, thereby leading to an increase in postsynaptic neuron discharge. In addition, activation of TACR2 can also cause neurons to release neurotransmitters, such as norepinephrine and glutamate, thereby regulating nervous system activity.

Pharmacological significance of TACR2

As a drug target, TACR2 has broad application prospects. Research shows that activation of TACR2 can cause excessive excitability of neurons and increase connections between neurons, thus leading to nervous system disorders. Therefore, TACR2 can be used as a drug target to treat the nervous system.

Biological significance of TACR2

Activation of TACR2 also has important biological significance. Activation of TACR2 can regulate autonomic nervous system activity and participate in complex biological processes, such as the regulation of blood sugar and blood pressure. In addition, activation of TACR2 can also affect the function of the immune system and participate in cellular immune responses and inflammatory responses.

The clinical significance of TACR2

The biological functions of TACR2 in the nervous system and immune system make it a potential drug target. For example, activation of TACR2 can be used to treat neurological pain, Parkinson's disease, Alzheimer's disease and other diseases. In addition, activation of TACR2 can also be used to treat diabetes and cardiovascular diseases in the endocrine system.

Pharmacokinetic significance of TACR2

The pharmacokinetic characteristics of TACR2 are also of great significance. Activation of TACR2 can lead to excessive excitability of neurons, so in drug research, attention needs to be paid to the antagonism of TACR2 to prevent neuronal damage caused by excessive activation. In addition, activation of TACR2 will also affect neuronal apoptosis. Therefore, TACR2 antagonists also need to have anti-neuronal apoptosis effects.

Biological value of TACR2

TACR2 plays an important role in the nervous system and immune system. Therefore, TACR2 is a drug target with broad application prospects. By antagonizing the activation of TACR2, various diseases in the nervous system and immune system can be treated.

Protein Name: Tachykinin Receptor 2

Functions: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P

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•   general information;
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