TAF11L2: A Potential Drug Target and Biomarker (G391742)

Target Name: TAF11L2

NCBI ID: G391742

TAF11L2

Other Name(s): Putative TAF11-like protein ENSP00000332601 | TFKL2_HUMAN | TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa pseudogene | TATA-box binding protein associated factor 11 like 2 | TATA-box binding protein associated factor 11 like protein 2 | TBP-associated factor 11 pseudogene

TAF11L2: A Potential Drug Target and Biomarker

Telomeres are repetitive DNA sequences that protect the ends of chromosomes from degradation and fusion. They are highly conserved across species and play a crucial role in ensuring the stability and longevity of chromosomes. TAF11L2 is a protein that belongs to the TAF11 family of proteins. This family has been identified as potential drug targets due to their involvement in a variety of cellular processes, including chromatin remodeling, DNA replication, and stress response.

The TAF11L2 protein is 21 kilobases (kb) in length and has a calculated molecular weight of 43.1 kdas. It is expressed in various cell types, including human breast cancer, lung cancer, and neuroblastoma cells. TAF11L2 is a glycoprotein with a single transmembrane region and a cytoplasmic tail. It consists of a catalytic domain, a nucleotide-binding domain, and a C-terminal TAF11-like domain.

The catalytic domain is the most conserved region of the TAF11L2 protein and is responsible for the protein's unique catalytic activity. It is a N-terminal alpha-helicase enzyme that has a molecular mechanism of ATP-dependent DNA cleavage. The nucleotide-binding domain is responsible for binding to DNA and is critical for the protein's function in chromatin remodeling and DNA replication. The C-terminal TAF11-like domain is a unique structural feature that is found only in TAF11L2 and has been implicated in the protein's stability and interaction with other cellular components.

TAF11L2 has been shown to play a crucial role in various cellular processes, including chromatin remodeling, DNA replication, and stress response. In addition to its role in DNA replication, TAF11L2 has also been shown to play a critical role in chromatin remodeling. This is evident from the fact that TAF11L2 is a component of the chromatin remodeling complex (CRC), which is responsible for reassembling chromatin after it has been damaged by various stressors, including UV radiation and chemicals.

In addition to its role in chromatin remodeling, TAF11L2 has also been shown to play a critical role in stress response. This is evident from the fact that TAF11L2 is a component of the stress response complex (SRC), which is responsible for monitoring and managing cellular stress. The SRC includes a variety of proteins that are involved in stress-induced signaling pathways, including the unfolded protein response (UPR), the DNA damage repair pathway, and the cell cycle.

The potential drug target for TAF11L2 is its role in cancer progression. TAF11L2 has been shown to be overexpressed in various types of cancer, including breast cancer, lung cancer, and neuroblastoma. This overexpression is associated with poor prognosis and increased cancer cell density. In addition, TAF11L2 has also been shown to promote the growth and survival of various cancer cell lines in cell culture.

The drug target for TAF11L2 is its role in cancer progression and its potential as a therapeutic agent. Research is currently being conducted to determine the efficacy and safety of targeting TAF11L2 as a drug candidate for various types of cancer. This includes studies are being conducted to determine the efficacy of TAF11L2-targeted therapeutics in animal models of cancer.

In conclusion, TAF11L2 is a protein that has been identified as a potential drug target due to its involvement in various cellular processes, including chromatin remodeling, DNA replication, and stress response. The TAF11L2 protein is expressed in various cell types and has been shown to play a crucial role in various cellular processes. The potential drug target for TAF11L2 is its role in cancer progression, and research is currently being conducted to determine its efficacy and safety as a therapeutic agent.

Protein Name: TATA-box Binding Protein Associated Factor 11 Like 2

The "TAF11L2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TAF11L2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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