TAF1C: A Protein Implicated in Immune Response and Potential Drug Targets

Target Name: TAF1C

NCBI ID: G9013

TAF1C

Other Name(s): TAFI95 | TAF1C variant 1 | TAFI110 | TATA-box binding protein associated factor, RNA polymerase I subunit C, transcript variant 5 | TATA box-binding protein-associated factor 1C | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa, transcript variant 1 | TATA-box binding protein associated factor, RNA polymerase I, C | TAF1C_HUMAN | TAF1C variant 5 | TATA box-binding protein-associated factor RNA polymerase I subunit C (isoform 4) | TATA-box binding protein associated factor, RNA polymerase I subunit C | RNA polymerase I-specific TBP-associated factor 110 kDa | Transcription factor SL1 | SL1, 110kD subunit | TBP-associated factor 1C | SL1 | TATA box binding protein associated factor 1C | TAF1C variant 4 | transcription initiation factor SL1/TIF-IB subunit C | MGC:39976 | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa | TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD | Transcription initiation factor SL1/TIF-IB subunit C | TATA-box binding protein associated factor, RNA polymerase I subunit C, transcript variant 4 | TATA box-binding protein-associated factor RNA polymerase I subunit C | transcription factor SL1 | TATA box-binding protein-associated factor RNA polymerase I subunit C (isoform 1)

TAF1C: A Protein Implicated in Immune Response and Potential Drug Targets

TAF1C (Tissue Antigen Fc Fragment 1C) is a protein that is expressed in various tissues throughout the body, including the lungs, heart, kidneys, and skin. It is a member of the superfamily of cytoplasmic antigens (SCAs), which are a group of proteins that are involved in the immune response. TAF1C is also known as TAF-1C and is classified as a type-I transmembrane protein.

The TAF1C protein is made up of several subunits that are held together by disulfide bonds. The subunits include a signal domain, a variable region, and a cytoplasmic tail. The signal domain is the region of the protein that contains the amino acids that are involved in the interaction with the cell surface. The variable region is the region of the protein that contains the amino acids that are specific to each subunit, and the cytoplasmic tail is the region of the protein that extends out of the cell membrane.

TAFI95 is a variant of TAF1C that has been shown to be a potential drug target in several diseases. TAFI95 is expressed in various tissues throughout the body, including the lungs, heart, kidneys, and skin. It is a type-I transmembrane protein that is made up of several subunits that are held together by disulfide bonds.

The TAF1C protein is involved in the immune response and has been implicated in several diseases. For example, TAF1C has been shown to be involved in the development and progression of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. It has also been shown to be involved in the regulation of inflammation and has been linked to the development of inflammatory diseases, such as heart failure and cancer.

TAFI95 has also been shown to be a potential drug target in diseases that are caused by the overproduction of proteins, such as genetic disorders and diseases caused by inflammation. It has been shown to interact with several proteins, including the transcription factor NF-kappa-B and the protein PDGF-尾.

In conclusion, TAF1C (TAFI95) is a protein that is expressed in various tissues throughout the body and is involved in the immune response. It has been shown to be a potential drug target in several diseases and has the potential to be used to treat a wide range of conditions. Further research is needed to fully understand the role of TAF1C in the immune response and to determine its potential as a drug target.

Protein Name: TATA-box Binding Protein Associated Factor, RNA Polymerase I Subunit C

Functions: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3

The "TAF1C Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TAF1C comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets