TACC3: A Promising Drug Target and Biomarker for Acidic Coiled-Coil Containing Proteins

Target Name: TACC3

NCBI ID: G10460

TACC3

TACC3: A Promising Drug Target and Biomarker for Acidic Coiled-Coil Containing Proteins

Acidic coiled-coil containing proteins (ACCP) have been identified as a promising drug target class in recent years due to their unique structure and function. These proteins often have multiple functions, including modulating ion channels, regulating protein-protein interactions, and playing a role in various cellular processes. One of the most well-studied ACCPs is Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3), which is a protein that has been shown to have multiple functions in various cellular processes, including cell signaling, DNA replication, and stress response.

TACC3: Structure and Function

TACC3 is a 25 kDa protein that is composed of 118 amino acid residues. It has a unique structure that consists of an N-terminal transmembrane domain, a coiled-coil domain, and an C-terminal cytoplasmic domain. The N-terminal transmembrane domain is responsible for the protein's ability to interact with various membrane receptors and other proteins, while the coiled-coil domain is responsible for its unique structure and function.

The coiled-coil domain of TACC3 is composed of a unique sequence that is specific to this protein. This sequence is composed of a series of amino acids that are highly conserved in various species, including humans, yeast, and bacteria. The sequence is responsible for the protein's ability to form a stable coiled structure, which allows it to interact with other proteins and molecules in a variety of ways.

TACC3 has been shown to have multiple functions in various cellular processes. One of its most well-studied functions is its role in cell signaling. TACC3 has been shown to play a role in the regulation of ion channels, including the regulation of the sodium/calcium ion channel. This is important for many cellular processes, including muscle contractions, nerve function, and brain activity.

Another function of TACC3 is its role in DNA replication. TACC3 has been shown to play a role in the regulation of DNA replication, which is important for the maintenance of genetic diversity and the development of new organisms. This function is critical for the growth and development of all living organisms, and is a function that is highly conserved across various species.

TACC3 has also been shown to play a role in stress response. TACC3 has been shown to be involved in the regulation of cellular stress responses, which are important for the survival of cells in a variety of environments. This function is critical for the regulation of cellular processes that are sensitive to stress, such as the regulation of inflammation and stress-induced cellular changes.

Drug Targeting and Biomarker

TACC3 is a drug target of great interest due to its unique structure and function. The N-terminal transmembrane domain of TACC3 has been shown to be a potential drug target, as it is involved in the regulation of cellular signaling. Several small molecules have been shown to interact with this domain and have been shown to have potential therapeutic effects.

In addition to its potential as a drug target, TACC3 is also a potential biomarker. The unique structure of TACC3 makes it a unique candidate for use as a biomarker for a variety of cellular processes. The coiled-coil domain of TACC3 has been shown to be highly conserved across various species, which suggests that it is a protein that is widely expressed in different organisms. This is important for the development of TACC3-based diagnostics and therapies, as it allows for the use of TACC3 as a biomarker for a variety of cellular processes.

Conclusion

TACC3 is a protein that has been shown to have

Protein Name: Transforming Acidic Coiled-coil Containing Protein 3

Functions: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476)

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