SZT2: A Potential Drug Target and Biomarker for Cardiovascular Disease

Target Name: SZT2

NCBI ID: G23334

SZT2

SZT2: A Potential Drug Target and Biomarker for Cardiovascular Disease

Introduction

S cardiovascular disease (CVD) remains one of the leading causes of morbidity and mortality worldwide, placing a significant burden on public health and economic development. The development of new therapeutic approaches to treat CVD is crucial for reducing these burden. One promising candidate for drug targeting and biomarker identification is SZT2 (SZT2 subunit of KICSTOR complex), a protein that has been identified as a potential drug target and biomarker for CVD. In this article, we will provide an overview of SZT2, its function in the KICSTOR complex, and its potential as a drug target and biomarker for CVD.

Function of SZT2 in the KICSTOR Complex

SZT2 is a 26-kDa protein that belongs to the KICSTOR (Kinetin-Intersensitive Contact Soup) complex. The KICSTOR complex is a protein-associated molecular machine (PAMM) that plays a crucial role in intracellular signaling. It consists of several subunits, including SZT2, KAT2, KTK1, and p21. SZT2 is a key subunit that interacts with other subunits of the KICSTOR complex to regulate various cellular processes, including cell signaling, DNA replication, and chromatin remodeling.

SZT2 is involved in the regulation of the activity of the KICSTOR complex. It functions as a negative regulator of the activity of the KAT2 subunit, which is responsible for the regulation of DNA replication and cell signaling. Specifically, SZT2 interacts with KAT2 and prevents it from activating the complex. This interaction between SZT2 and KAT2 inhibits the activity of the KICSTOR complex, which is involved in the regulation of DNA replication, cell proliferation, and apoptosis.

Potential Drug Target and Biomarker for CVD

The identification of potential drug targets and biomarkers for CVD is an important step in the development of new therapeutic approaches. SZT2, as a key subunit of the KICSTOR complex, is a promising candidate for drug targeting and biomarker research. Several studies have shown that inhibiting the activity of SZT2 can lead to the inhibition of the KICSTOR complex, which may have implications for the regulation of cellular processes that are involved in CVD development.

One potential mechanism by which SZT2 may contribute to the development of CVD is its role in the regulation of cellular signaling pathways that are involved in the development of plaque in the arterial walls. SZT2 has been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed to supply oxygen and nutrients to the body's tissues. Studies have shown that SZT2 plays a role in the regulation of angiogenesis by the KICSTOR complex.

Another potential mechanism by which SZT2 may contribute to the development of CVD is its role in the regulation of cellular processes that are involved in inflammation and stress responses. SZT2 has been shown to be involved in the regulation of inflammation and stress responses by the KICSTOR complex . Studies have shown that SZT2 plays a role in the regulation of inflammation by the KICSTOR complex, by interacting with the transcription factor nuclear factor NF-kappa-B.

In addition, SZT2 has also been shown to be involved in the regulation of cellular processes that are involved in the regulation of cellular apoptosis.

Protein Name: SZT2 Subunit Of KICSTOR Complex

Functions: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose (PubMed:28199306, PubMed:28199315). May play a role in the cellular response to oxidative stress (By similarity)

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