TAF-1: A Potential Drug Target for Various Diseases (G6872)

Target Name: TAF1

NCBI ID: G6872

TAF1

TAF-1: A Potential Drug Target for Various Diseases

TAF-1 (TAF(II)250) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of the cell cycle, and is involved in the development and maintenance of normal cell structure and function.

Recent studies have identified TAF-1 as a potential drug target for a variety of diseases, including cancer, neurodegenerative diseases, and developmental disorders. This is because TAF-1 has been shown to be involved in the regulation of many important cellular processes, and is often disrupted in diseases.

One of the key reasons for the potential of TAF-1 as a drug target is its involvement in the regulation of the cell cycle. The cell cycle is the process by which cells grow, divide, and replicate themselves. TAF-1 is a key regulator of the cell cycle, and has been shown to play a role in the regulation of cell division, as well as the progression of the cell cycle.

Studies have shown that TAF-1 is involved in the regulation of the G1/S transition, which is the stage of the cell cycle where the cell prepares for cell division. During the G1/S transition, TAF-1 is thought to help ensure that the cell has enough copies of its genetic material to divide, and that the cell prepares properly for cell division by producing the necessary proteins and organelles.

In addition to its role in the cell cycle, TAF-1 has also been shown to be involved in the regulation of cell survival. Studies have shown that TAF-1 plays a role in the regulation of cell survival by helping to maintain the integrity of the cell membrane. This is important for the survival of the cell, as a damaged or broken cell membrane can allow substances to enter the cell and cause it to die.

The potential of TAF-1 as a drug target is also due to its involvement in the regulation of many other cellular processes. For example, TAF-1 has been shown to be involved in the regulation of cell adhesion, cell migration, and the production of intracellular signaling molecules.

In conclusion, TAF-1 is a protein that is expressed in various tissues of the body, and is involved in the regulation of the cell cycle, as well as many other cellular processes. Its potential as a drug target is due to its involvement in the development and maintenance of normal cell structure and function, as well as its involvement in the regulation of cell survival and many other cellular processes. Further research is needed to fully understand the potential of TAF-1 as a drug target for various diseases.

Protein Name: TATA-box Binding Protein Associated Factor 1

Functions: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed:25412659, PubMed:27007846, PubMed:33795473). TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (PubMed:33795473). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors (PubMed:25412659, PubMed:8625415). Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (PubMed:25412659). Phosphorylates GTF2A1 and GTF2F1 on Ser residues (PubMed:25412659). Possesses DNA-binding activity (PubMed:25412659). Essential for progression of the G1 phase of the cell cycle (PubMed:11278496, PubMed:15053879, PubMed:2038334, PubMed:8450888, PubMed:8625415, PubMed:9660973, PubMed:9858607). Exhibits histone acetyltransferase activity towards histones H3 and H4 (PubMed:15870300)

The "TAF1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TAF1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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