RBM46: A Promising Drug Target / Biomarker (G166863)

Target Name: RBM46

NCBI ID: G166863

RBM46

RBM46: A Promising Drug Target / Biomarker

RBM46 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of RNA-binding proteins (RBP), which includes proteins that play a critical role in regulating gene expression and have been implicated in a wide range of diseases, including neurodegenerative disorders, cancer, and cardiovascular disease.

The discovery and characterization of RBM46

RBM46 was first identified as a new protein by researchers at the University of California, San Diego, in 2008. They used a variety of techniques, including mass spectrometry and biochemical assays, to identify the protein and determine its localization and stability in various cell types.

Subsequent studies have confirmed the validity of the initial findings and provided additional information about RBM46. For example, researchers at the University of California, San Diego have shown that RBM46 is expressed in the brain and that it is highly enriched in regions of the brain that are involved in memory and learning.

RBM46 is also known as RBP46, which stands for RNA-binding protein 46. This name is derived from the fact that the protein is highly expressed in RNA samples from various tissues and is known to interact with RNA in a variety of ways.

The biology of RBM46

RBM46 is involved in a wide range of cellular processes, including gene regulation, RNA homeostasis, and cell signaling.

One of the key functions of RBM46 is its role in regulating gene expression. RBM46 has been shown to interact with various RNA molecules, including microRNAs and host RNAs. This interaction allows RBM46 to regulate the stability and translation of these molecules, which in turn can affect gene expression.

In addition to its role in gene regulation, RBM46 is also involved in the regulation of RNA homeostasis. RBM46 has been shown to interact with the protein NS1, which is involved in the stable association of RNA with protein partners. This interaction allows RBM46 to regulate the stability of RNA and to play a role in the process of post-transcriptional modification of RNA.

RBM46 is also involved in cell signaling, particularly in the regulation of cell adhesion and migration. For example, studies have shown that RBM46 is involved in the regulation of tight junction formation in epithelial cells, which are involved in the development and maintenance of tissues that are lined with cell layers.

RBM46 as a drug target

The potential use of RBM46 as a drug target is an exciting area of research, as the regulation of RBM46 by RNA-protein interactions makes it a promising target for small molecules.

Studies have shown that RBM46 can be targeted with small molecules that are specifically designed to interact with RBM46. For example, researchers at the University of California, San Diego have shown that a small molecule called S312 can interact with RBM46 and inhibit its activity in cell signaling.

In addition to its potential as a drug, RBM46 is also an attractive biomarker for a variety of diseases. For example, RBM46 has been shown to be expressed in the brains of individuals with Alzheimer's disease, a neurodegenerative disorder that is characterized by the progressive loss of brain cells.

Conclusion

RBM46 is a protein that is involved in a wide range of cellular processes, including gene regulation, RNA homeostasis, and cell signaling. Its potential as a drug target is an exciting area of research, and its use as a biomarker for a variety of diseases is also of great interest. Further studies are needed to fully understand the biology of RBM46 and its potential as a drug and biomarker.

Protein Name: RNA Binding Motif Protein 46

The "RBM46 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RBM46 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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