DHODH: A Drug Target / Disease Biomarker (G1723)

Target Name: DHODH

NCBI ID: G1723

DHODH

DHODH: A Drug Target / Disease Biomarker

DHODH, short for Dimerized Homodimeric HSP70, is a protein that is expressed in various tissues throughout the body. It is a heat-labile protein that has been shown to play a role in a variety of cellular processes, including cell signaling, inflammation, and stress response.

One of the unique features of DHODH is its ability to form homodimers, which are the same structure of protein that is found in all cells. This is important for the protein to function properly and for it to be able to interact with other proteins.

DHODH has also been shown to play a role in the detoxification of harmful substances in the body, such as drugs and other toxins. This is done through its ability to interact with the metal ion aryl hydroxylase (MAA) enzyme, which is responsible for breaking down harmful substances in the body.

Another function of DHODH is its role in the immune system. It has been shown to be involved in the regulation of T cell responses, which are important for the immune system to function properly.

DHODH has also been shown to play a role in the regulation of cell death, which is important for the maintenance of tissue homeostasis.

In addition to its role in cell signaling and immune function, DHODH has also been shown to play a role in the regulation of inflammation. It has been shown to have anti-inflammatory properties and to play a role in the regulation of the production of pro-inflammatory cytokines.

DHODH has also been shown to have potential as a drug target. Studies have shown that DHODH can be targeted with small molecules and antibodies, which could make it a useful target for the development of new pharmaceuticals.

In addition to its potential as a drug target, DHODH is also a potential biomarker for a variety of diseases. Studies have shown that changes in the levels of DHODH can be associated with a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Overall, DHODH is a protein that has a wide range of functions in various cellular processes throughout the body. Its ability to form homodimers and its role in cell signaling, detoxification, immune function, and inflammation make it a promising target for the development of new pharmaceuticals and biomarkers. Further research is needed to fully understand its role in these processes and its potential as a drug target and biomarker.

Protein Name: Dihydroorotate Dehydrogenase (quinone)

Functions: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway

The "DHODH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DHODH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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