EIF4E: A Potential Drug Target and Biomarker (G1977)

Target Name: EIF4E

NCBI ID: G1977

EIF4E

EIF4E: A Potential Drug Target and Biomarker

EIF4E (endoplasmic reticulum-associated protein 4E) is a protein that is expressed in various cell types of the human body. Its function is not well understood, but it is known to play a role in the transport of proteins to the endoplasmic reticulum (ER), which is the site of protein synthesis and folding. EIF4E has also been shown to be involved in the regulation of cellular processes such as cell adhesion, migration, and survival.

Recent studies have suggested that EIF4E may have potential as a drug target or biomarker. In this article, we will explore the potential mechanisms by which EIF4E can be targeted by small molecules and its potential as a biomarker for various diseases.

EIF4E as a Drug Target

One of the potential mechanisms by which EIF4E can be targeted by small molecules is through its role in the ER-associated degradation (ERD) pathway. ERD is a process by which proteins that are not targeted for degradation by the endoplasmic reticulum are removed and degraded. This process is critical for maintaining the protein inventory of the ER and is thought to be involved in various cellular processes, including protein folding and signaling.

Several studies have shown that small molecules can inhibit ERD, leading to increased levels of EIF4E in the ER. This increased expression of EIF4E can then lead to its accumulation in the endoplasmic reticulum, potentially leading to its activation and subsequent degradation.

Another potential mechanism by which EIF4E can be targeted by small molecules is through its role in the regulation of cellular adhesion. Adhesion is a process by which cells stick together and form tissues. EIF4E has been shown to play a role in the regulation of cell adhesion, and small molecules that can modulate its function have been shown to affect cellular adhesion.

EIF4E as a Biomarker

EIF4E has also been suggested as a potential biomarker for various diseases. One of the main advantages of using EIF4E as a biomarker is its expression is known to be sensitive to various diseases, making it a potential diagnostic tool.

For example, EIF4E has been shown to be expressed in various types of cancer, including breast, lung, and ovarian cancer. This suggests that EIF4E could be used as a biomarker for cancer, particularly in the early stages of disease.

Another potential application of EIF4E as a biomarker is its role in the regulation of cellular processes, such as cell migration. EIF4E has been shown to play a role in the regulation of cell migration and has been implicated in various diseases, including neurodegenerative disorders.

In conclusion, EIF4E is a protein that has not yet been fully understood, but it is known to play a role in various cellular processes. Its potential as a drug target or biomarker makes it an attractive target for further research. Further studies are needed to fully understand the mechanisms by which EIF4E can be targeted by small molecules and its potential as a biomarker for various diseases.

Protein Name: Eukaryotic Translation Initiation Factor 4E

Functions: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:16271312, PubMed:22578813). In addition to its role in translation initiation, also acts as a regulator of translation and stability in the cytoplasm (PubMed:24335285). Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression: in the complex, EIF4E mediates the binding to the mRNA cap (By similarity). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). In P-bodies, component of a complex that mediates the storage of translationally inactive mRNAs in the cytoplasm and prevents their degradation (PubMed:24335285). May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity)

The "EIF4E Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EIF4E comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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