EMX2: The Homeobox Protein EMX2 (G2018)

Target Name: EMX2

NCBI ID: G2018

EMX2

EMX2: The Homeobox Protein EMX2

The Homeobox (Hox) gene family plays a crucial role in the development and maintenance of normal tissue structure and function. Hox genes are involved in the regulation of cellular processes such as growth, differentiation, and pattern formation. TheEMX2 gene is a member of the Hox gene family and is expressed in a variety of tissues throughout the body.

EMX2: Structure and Function

EMX2 is a 21-kDa transmembrane protein that is expressed in various tissues, including neural, muscle, and epithelial cells. It is characterized by a N-terminal region that contains a putative homeobox domain, a central region that contains a conserved zinc finger motif, and a C-terminal region that contains a carboxylic acid-rich region and a leucinerich repeat.

The N-terminal region of EMX2 contains a 24 amino acid residue long sequence that is similar to the N-terminal region of other Hox genes. This region is involved in the formation of a complex with the transcription factor p53, which plays a role in the regulation of gene expression.

The central region of EMX2 contains a conserved zinc finger motif that is commonly found in the Hox gene family. This motif is responsible for the formation of a Zn-fold that can interact with various transcription factors to regulate gene expression.

The C-terminal region of EMX2 is the largest and most well-studied region of the protein. It is involved in the formation of a carboxylic acid-rich region that can interact with various enzymes involved in cellular signaling pathways. This region also contains a leucinerich repeat, which is a common structural feature in the Hox gene family.

EMX2: Biological Functions

EMX2 is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and survival. It is a key regulator of the development and maintenance of normal tissue structure and function.

EMX2 is involved in the regulation of cell growth and differentiation. It has been shown to play a role in the regulation of cell proliferation and the maintenance of normal cell size. In addition, EMX2 is involved in the regulation of cell differentiation and the regulation of cell-cell adhesion.

EMX2 is involved in the regulation of cellular signaling pathways. It has been shown to play a role in the regulation of various signaling pathways, including the TGF-β pathway and the Wnt pathway. This suggests that EMX2 may be involved in the regulation of cellular processes that are critical for normal development and maintenance.

EMX2 is involved in the regulation of cellular stress responses. It has been shown to play a role in the regulation of cellular stress responses, including the regulation of cell survival and the regulation of cellular inflammation.

Conclusion

EMX2 is a member of the Hox gene family and is expressed in a variety of tissues throughout the body. It is characterized by a N-terminal region that contains a putative homeobox domain, a central region that contains a conserved zinc finger motif, and a C-terminal region that contains a carboxylic acid-rich region and a leucinerich repeat. EMX2 is involved in the regulation of a wide range of cellular processes, including cell growth, differentiation, and survival. It is a potential drug target and may be useful in the development of new therapeutic strategies for a variety of diseases.

Protein Name: Empty Spiracles Homeobox 2

Functions: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system

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