ENG: A Potential Drug Target for Cardiovascular and Neurodegenerative Diseases

Target Name: ENG

NCBI ID: G2022

Content of Review Report on ENG Target / Biomarker

ENG

ENG: A Potential Drug Target for Cardiovascular and Neurodegenerative Diseases

ENG (endoglin) is a protein that is expressed in the endothelium, which is the lining of the blood vessels. It is a potent biomarker for the diagnosis and prognosis of various cardiovascular diseases, including heart failure, hypertension, and cancer.

ENG has been shown to play a crucial role in the regulation of cardiovascular function and has been linked to the development and progression of cardiovascular disease. It has been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed, and has been shown to play a role in the regulation of vascular permeability.

ENG has also been shown to be involved in the regulation of cellular signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and has been implicated in the development and progression of various diseases, including cancer.

ENG has also been shown to be involved in the regulation of the immune response. It has been shown to play a role in the regulation of immune cell recruitment and activation, and has been implicated in the development of autoimmune diseases.

In addition to its role in cardiovascular and immune function, ENG has also been shown to be involved in the regulation of cellular signaling pathways that are involved in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Overall, ENG is a protein that has the potential to be a drug target or biomarker for a variety of cardiovascular and neurodegenerative diseases. Further research is needed to fully understand its role and potential applications in these fields.

Protein Name: Endoglin

Functions: Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PubMed:21737454, PubMed:23300529). Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells (PubMed:17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors (PubMed:1692830). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PubMed:8370410, PubMed:21737454, PubMed:22347366, PubMed:23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (PubMed:21737454, PubMed:22347366, PubMed:23300529)

The "ENG Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ENG comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets