TAPT1: A Potential Drug Target and Biomarker for Transmembrane Transformation 1

Target Name: TAPT1

NCBI ID: G202018

TAPT1

TAPT1: A Potential Drug Target and Biomarker for Transmembrane Transformation 1

Transmembrane transformation 1 (TMP1) is a process that involves the transformation of the outer membrane of a cell into a periplasmic space, which is vital for various cellular functions. TMP1 plays a crucial role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, targeting TMP1 has become an attractive research focus in recent years.

TAPT1, the Transmembrane Anterior Posterior Transformation 1 protein, is a key player in the regulation of TMP1. TAPT1 functions as a negative regulator of TMP1, preventing it from undergoing a conformational change that would lead to its ability to transform the outer membrane of cells into the periplasmic space. The study of TAPT1 has significant implications for our understanding of TMP1 function and its potential as a drug target or biomarker.

Understanding TAPT1: Structure and Function

TAPT1 is a 21-kDa protein that is expressed in various cell types, including epithelial, endothelial, and muscle cells. It is composed of a transmembrane region, an intracellular region, and an extracellular region. The transmembrane region consists of two distinct domains: an N-terminal domain and a C-terminal domain.

The N-terminal domain is responsible for the formation of a complex with TMP1, which is critical for TAPT1's stability and function. The C-terminal domain is involved in TAPT1's interaction with various cellular signaling pathways, including the TGF-β pathway.

TAPT1 functions as a negative regulator of TMP1 through its ability to block the formation of a stable complex between TMP1 and its N-terminal domain. This blockade prevents TMP1 from undergoing a conformational change that would lead to its ability to transform the outer membrane of cells into the periplasmic space.

In addition to its role in regulating TMP1, TAPT1 has also been shown to play a significant role in the regulation of various cellular processes, including cell adhesion, migration, and invasion. TAPT1 has been shown to regulate the activity of several cytoskeleton-associated proteins, including actinin and microtubules, which are critical for the movement of cells along various signaling pathways.

TAPT1 as a Drug Target

TAPT1's role in the regulation of TMP1 and its involvement in various cellular processes make it an attractive drug target. Several studies have shown that inhibition of TAPT1 can lead to a reduction in the activity of TMP1 and its downstream targets, such as actinin and microtubules.

One of the most promising compounds that has been shown to inhibit TAPT1 is curcumin, an isorhapontane-based natural product derived from turmeric. Curcumin has been shown to inhibit the activity of TAPT1 and its downstream targets, including actinin and microtubules.

In addition to its potential as a drug target, curcumin also has several potential benefits as a therapeutic agent. Curcumin has been shown to have anti-inflammatory and antioxidant properties, which could make it an effective agent for the treatment of various inflammatory and neurodegenerative diseases.

TAPT1 as a Biomarker

TAPT1 is also an attractive biomarker for the diagnosis and monitoring of various diseases, including cancer and neurodegenerative disorders. Since TAPT1 is involved in the regulation of TMP1, its levels have been shown to be affected by several diseases, including cancer.

Studies have shown that TAPT1 levels are often elevated in various types of cancer, including breast, ovarian, and prostate cancer. This increase in TAPT1 levels could be an indication of the disease and could be used as a biomarker for

Protein Name: Transmembrane Anterior Posterior Transformation 1

Functions: Plays a role in primary cilia formation (PubMed:26365339). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity)

The "TAPT1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TAPT1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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