TARP Protein: A Promising Drug Target and Biomarker (G445347)

Target Name: TARP

NCBI ID: G445347

TARP

TARP Protein: A Promising Drug Target and Biomarker

Introduction

TARP (TARP protein) is a protein that plays a crucial role in various cellular processes. It is a transmembrane protein that is involved in various signaling pathways, including inflammation, cell signaling, and metabolism. TARP protein has been identified as a potential drug target and biomarker due to its unique structure, expression, and function.

Structure and Expression

TARP protein is a 21-kDa protein that consists of a N-terminal transmembrane domain, a coiled-coil domain, and a C-terminal cytoplasmic domain. The N-terminal transmembrane domain is the region of the protein that interacts with extracellular signaling molecules , while the coiled-coil domain is responsible for the protein's dynamic structure and function. The C-terminal cytoplasmic domain is involved in protein-protein interactions and may contribute to the protein's stability.

TARP protein is expressed in various tissues and cells, including brain, heart, liver, and muscle. It is primarily expressed in the cytoplasm of cells and is also found in the endoplasmic reticulum (ER) and the nuclear envelope (NE). has been shown to be involved in various cellular processes, including cell signaling, DNA replication, and metabolism.

Drug Target Potential

TARP protein has been identified as a potential drug target due to its unique structure and function. The N-terminal transmembrane domain of TARP protein contains several potential drug-binding sites, including an interaction with small molecules, such as inhibitors of the protein's phosphorylating activity . Additionally, the coiled-coil domain of TARP protein is involved in the formation of the protein's dimeric state, which may make it more susceptible to inhibitors that can disrupt the protein's dimeric state.

TARP protein has also been shown to play a role in various signaling pathways, including the production of reactive oxygen species (ROS) and the regulation of inflammation. TARP protein has been shown to be involved in the production of ROS by NADPH oxidase (NOX) , a protein that is involved in the production of ROS from NADPH. Additionally, TARP protein has been shown to be involved in the regulation of inflammation by suppressing the production of pro-inflammatory cytokines.

Biomarker Potential

TARP protein has also been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. TARP protein has been shown to be involved in the regulation of cellular processes that are altered in various diseases, including cancer, neurodegenerative diseases. , and cardiovascular diseases.

For example, TARP protein has been shown to be involved in the regulation of cell proliferation, which is altered in cancer cells. Additionally, TARP protein has been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. TARP protein has also been shown to be involved in the regulation of cardiovascular diseases, including heart failure and hypertension.

Conclusion

TARP protein is a unique protein that plays a crucial role in various cellular processes. Its unique structure and expression make it a potential drug target and biomarker. The N-terminal transmembrane domain of TARP protein contains several potential drug-binding sites, while the coiled -coil domain is involved in the protein's dynamic structure and function. TARP protein has been shown to be involved in various cellular processes, including cell signaling, DNA replication, and metabolism. Additionally, TARP protein has been shown to play a role in the production of ROS and the regulation of inflammation. Its potential as a drug target and biomarker makes it an attractive target for future research.

Protein Name: TCR Gamma Alternate Reading Frame Protein

The "TARP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TARP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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