TAS1R2: A Potential Drug Target and Biomarker for Taste and Molecular Mechanisms of Olfaction

Target Name: TAS1R2

NCBI ID: G80834

TAS1R2

TAS1R2: A Potential Drug Target and Biomarker for Taste and Molecular Mechanisms of Olfaction

Taste and smell are two important parts of the human sensory system and play a vital role in individual survival and daily activities. They play a key role in identifying irritants such as food, drugs, chemicals, etc. In certain disease states, such as diabetes, cancer, etc., an individual's ability to perceive and identify stimuli such as food and drugs will be affected. Therefore, it is of important clinical significance to study the molecular mechanism of TAS1R2 and reveal its impact on taste and smell.

The TAS1R2 receptor, or TAS1R2, is a G protein-coupled receptor (GPCR) that is mainly expressed on the taste bud cells of the tongue. It plays an important role in taste perception such as mouthfeel, sweetness and bitterness. The TAS1R2 receptor has seven transmembrane 伪-helix structures, including a short GPCR伪 domain, a long GPCR尾 domain and a GPCR纬 domain. The TAS1R2 receptor can bind to a variety of ligands, including bitters, sweeteners, and drugs. Studies have found that the TAS1R2 receptor plays an important role in bitter taste perception and can be used as a potential drug target.

Research on the role of TAS1R2 receptors in drug targets mainly focuses on the following aspects:

1. Anti-tumor effect: Research has found that the TAS1R2 receptor plays an important role in tumor growth and metastasis. TAS1R2 receptor-positive tumor cells have stronger growth and metastasis capabilities in vivo. Therefore, the TAS1R2 receptor has become an important anti-tumor target. Currently, some anti-tumor drugs targeting the TAS1R2 receptor are already in clinical use. For example, studies have shown that TAS1R2 receptor antagonists can significantly inhibit tumor growth and metastasis.

2. Hypoglycemic effect: The role of TAS1R2 receptor in diabetes treatment has also received widespread attention. Studies have found that TAS1R2 receptors have higher expression levels in diabetic patients, and TAS1R2 receptor-positive individuals have poorer responses to drugs. Therefore, the TAS1R2 receptor is considered a potential diabetes drug target. Currently, some antidiabetic drugs targeting the TAS1R2 receptor are already in clinical trials. For example, studies have shown that TAS1R2 receptor antagonists can significantly reduce blood sugar levels.

3. Anti-inflammatory effect: TAS1R2 receptor also plays an important role in anti-inflammatory effect. Studies have found that the TAS1R2 receptor plays an important role in inflammatory responses and can be used as a potential anti-inflammatory drug target. Currently, some anti-inflammatory drugs targeting TAS1R2 receptors are already in clinical use. For example, studies have shown that TAS1R2 receptor antagonists can significantly reduce inflammatory responses.

4. Drug interaction: TAS1R2 receptor also plays an important role in drug interaction. Studies have found that the TAS1R2 receptor can interact with other drug receptors and affect the absorption, distribution and excretion of drugs. Therefore, the TAS1R2 receptor has important guiding significance in drug development and clinical application.

Research on TAS1R2 receptors provides new ideas and methods for drug development. Through in-depth study of the molecular mechanism of TAS1R2 receptor in bitter taste perception, tumor growth, diabetes treatment and anti-inflammatory effects, it is expected to provide new targets for the development of new drugs. At the same time, the TAS1R2 receptor, as a potential drug target, has broad application prospects in future drug development and clinical applications.

Protein Name: Taste 1 Receptor Member 2

Functions: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners

The "TAS1R2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TAS1R2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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