ALDH2: A Potential Drug Target for Many Diseases (G217)

Target Name: ALDH2

NCBI ID: G217

ALDH2

ALDH2: A Potential Drug Target for Many Diseases

ALDH2 (Aldehyde:NAD+ oxidoreductase) is a enzyme that plays a crucial role in the detoxification of harmful substances in the body. It is found in many different cell types throughout the body, including the liver, and is responsible for converting toxic aldehydes into less toxic compounds.

The activity of ALDH2 has been linked to a number of potential health benefits, including its ability to protect against oxidative stress and its role in the detoxification of harmful substances that can accumulate in the body over time. It is also expressed in many different tissues and has been shown to be involved in a wide range of cellular processes, including cell signaling, DNA replication, and the regulation of cell growth.

Despite its many functions, ALDH2 is currently a drug target for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the main reasons for the interest in ALDH2 is its potential as a drug target is its ability to modulate the activity of other enzymes. Many drugs work by inhibiting the activity of certain enzymes, and by doing so they can either activate or inhibit the activity of other enzymes. This is known as pharmacological intervention and can be a powerful tool for treating disease.

One of the ways that ALDH2 has been shown to be involved in drug resistance is by its role in the detoxification of drugs. Many drugs, including chemotherapy drugs, are able to produce reactive aldehydes that can inhibit the activity of ALDH2 and make them more toxic. This is why ALDH2 has been shown to be an attractive target for cancer therapy.

Another way that ALDH2 has been shown to be involved in drug resistance is by its role in the detoxification of neurotoxins. Many neurotoxins, including those that cause neurodegenerative diseases, are able to produce reactive aldehydes that can inhibit the activity of ALDH2 and make them more toxic. This is why ALDH2 has also been shown to be an attractive target for neurodegenerative disease therapy.

In addition to its role in drug resistance, ALDH2 has also been shown to be involved in a number of other cellular processes that are important for human health. For example, it has been shown to be involved in the regulation of cell growth, cell signaling, and DNA replication. It has also been shown to play a role in the detoxification of harmful substances that can accumulate in the body over time, such as those that are produced by the metabolism of certain medications.

Despite its many functions, ALDH2 is not without potential drawbacks. One of the main challenges in studying ALDH2 is its complex structure and the fact that it is expressed in many different tissues. This makes it difficult to study its effects in isolation and to determine exactly how it works. In addition, ALDH2 is a relatively simple enzyme and is not well understood in many details.

In conclusion, ALDH2 is an enzyme that plays a crucial role in the detoxification of harmful substances in the body. Its activity has been linked to a number of potential health benefits, including its ability to protect against oxidative stress and its role in the detoxification of harmful substances. It is also expressed in many different tissues and has been shown to be involved in a wide range of cellular processes. While its potential as a drug target is still being studied, its role in drug resistance and its potential benefits for a wide range of diseases make it an attractive target for further research.

Protein Name: Aldehyde Dehydrogenase 2 Family Member

Functions: Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage

The "ALDH2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ALDH2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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