PHLDB1: A Protein Involved in Signaling Pathways and Drug Targets

Target Name: PHLDB1

NCBI ID: G23187

PHLDB1

PHLDB1: A Protein Involved in Signaling Pathways and Drug Targets

PHLDB1 (PHLDB1_HUMAN) is a protein that is expressed in various tissues of the human body. It is a part of the phosphatidylinositol signaling pathway, which is a well-established pathway involved in various cellular processes, including cell signaling , protein synthesis, and cellular signaling.

The PHLDB1 protein is a key regulator of this pathway, and its function is to catalyze the transfer of a phosphate group from the intracellular calcium ion (Ca2+) to the regulatory protein IP3 (inositol trisphosphate). This transfer of the phosphate group from Ca2+ to IP3 is a critical step in the phosphatidylinositol signaling pathway, and it allows for the production of various signaling molecules, including inositol, which plays a crucial role in cell signaling.

PHLDB1 is a protein that can be targeted by small molecules, which makes it an attractive drug target. Studies have shown that the addition of small molecules to the intracellular environment can cause changes in the expression and activity of PHLDB1. For example, one study found that the addition of an inhibitor of the protein kinase CK2 (CK2 kinase 2) to the culture medium inhibited the phosphorylation of PHLDB1 and IP3, suggesting that PHLDB1 is a target for this kinase.

Another study found that the addition of a small molecule inhibitor of the protein tyrosine kinase (PTK) to the culture medium inhibited the phosphorylation of PHLDB1 and IP3, further supporting the idea that PHLDB1 is a target for PTK.

In addition to its role in the phosphatidylinositol signaling pathway, PHLDB1 is also involved in the regulation of various cellular processes, including cell adhesion, migration, and the development of cancer. For example, studies have shown that PHLDB1 plays a critical role in the regulation of cell adhesion and migration, and that its expression is often associated with the development of cancer.

Furthermore, PHLDB1 is also involved in the regulation of various signaling pathways, including the TGF-灏? (transforming growth factor-灏?) signaling pathway, which is involved in cell growth, differentiation, and repair. Studies have shown that PHLDB1 plays a critical role in the regulation of TGF-灏? signaling pathway, and that its expression is often associated with the regulation of TGF-灏? signaling.

In conclusion, PHLDB1 is a protein that is involved in various cellular processes and is a key regulator of the phosphatidylinositol signaling pathway. Its function is to catalyze the transfer of a phosphate group from the intracellular calcium ion to the regulatory protein IP3. The addition of small molecules to the intracellular environment can cause changes in the expression and activity of PHLDB1, and its regulation by various signaling pathways suggests that it is an attractive drug target. Further studies are needed to fully understand the role of PHLDB1 in cellular processes and its potential as a drug target.

Protein Name: Pleckstrin Homology Like Domain Family B Member 1

The "PHLDB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHLDB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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