CASKIN2: A Potential Drug Target and Biomarker (G57513)

Target Name: CASKIN2

NCBI ID: G57513

CASKIN2

CASKIN2: A Potential Drug Target and Biomarker

Caskin-2 (ISOform A) is a protein that is expressed in various tissues of the body, including the brain, heart, and liver. It is a member of the Caskin-2 family of proteins, which are known for their role in intracellular signaling. One of the unique features of Caskin-2 is its ability to interact with the protein p120GAP, which is a key regulator of the PI3K/Akt signaling pathway. This interaction between Caskin-2 and p120GAP has led to the hypothesis that Caskin-2 may be a drug target or biomarker for various diseases. In this article, we will explore the potential of Caskin-2 as a drug target and biomarker.

Drug Target Potential

Caskin-2 has been shown to play a role in various signaling pathways, including the PI3K/Akt signaling pathway. This pathway is involved in many cellular processes, including cell growth, differentiation, and survival. p120GAP is a protein that can activate the PI3K/Akt signaling pathway by interacting with the protein PDZP (Pyruvate-Protein Ligase). The interaction between Caskin-2 and p120GAP has led to the hypothesis that Caskin-2 may be a drug target.

One of the potential drug targets for Caskin-2 is cancer. Cancer is a disease that is characterized by the uncontrolled growth and spread of cells. The PI3K/Akt signaling pathway is often aberrantly activated in cancer cells, leading to the development of a variety of signaling pathways that promote cell growth, survival, and angiogenesis. Caskin-2 has been shown to play a role in the regulation of the PI3K/Akt signaling pathway, and targeting it may be a promising approach to cancer treatment.

Another potential drug target for Caskin-2 is neurodegenerative diseases, such as Alzheimer's disease. The PI3K/Akt signaling pathway is involved in the regulation of many cellular processes that are important for brain function, including the formation of neurotransmitters, the regulation of inflammation, and the maintenance of brain cells. The dysfunction of the PI3K/Akt signaling pathway has been implicated in the development and progression of neurodegenerative diseases. Caskin-2 has been shown to play a role in the regulation of the PI3K/Akt signaling pathway in brain cells, and targeting it may be a promising approach to the treatment of neurodegenerative diseases.

Biomarker Potential

Caskin-2 has also been shown to be a potential biomarker for various diseases. The PI3K/Akt signaling pathway is involved in the regulation of many cellular processes, including cell growth, differentiation, and survival. The dysfunction of this pathway has been implicated in the development and progression of many diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

One of the potential applications of Caskin-2 as a biomarker is the detection and monitoring of disease progression. The PI3K/Akt signaling pathway is often altered in diseases, and the levels of various proteins, including Caskin-2, may be altered as well. The detection of changes in the levels of Caskin-2 or other proteins involved in the PI3K/Akt signaling pathway may be a promising approach to the detection and monitoring of disease progression.

Another potential application of Caskin-2 as a biomarker is the development of new therapeutic approaches. The PI3K/Akt signaling pathway is involved in the regulation of many cellular processes, and the dysfunction

Protein Name: CASK Interacting Protein 2

The "CASKIN2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CASKIN2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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