FBXW11: A Potential Drug Target and Biomarker (G23291)

Target Name: FBXW11

NCBI ID: G23291

FBXW11

FBXW11: A Potential Drug Target and Biomarker

FacebookeXpress Web 1.1 (Hos) is a protein that is expressed in various tissues throughout the body, including the brain, heart, kidneys, and liver. It is a member of the superfamily of cytoplasmic proteins, which are a type of protein that is found in all eukaryotic cells.

Hos is involved in a number of different cellular processes in the body, including the regulation of cell signaling pathways, the transport of molecules across cell membranes, and the regulation of inflammation. It is also involved in the development and maintenance of the brain, and has been shown to play a role in a number of neurological and psychiatric disorders, including Alzheimer's disease and depression.

One of the most promising aspects of FBXW11 is its potential as a drug target. FBXW11 has been shown to interact with a number of different molecules, including G protein-coupled receptors (GPCRs), which are a type of protein that is involved in a variety of cellular processes, including sensory perception and neurotransmission.

GPCRs are a family of transmembrane proteins that are involved in the regulation of a wide range of cellular processes, including cell signaling, ion channels, and neurotransmission. They are involved in the development and maintenance of many different tissues and organs, including the brain and nervous system.

One of the ways that FBXW11 interacts with GPCRs is through its ability to modulate the activity of these proteins. For example, studies have shown that FBXW11 can interact with the GPCR known as GLR-1, which is involved in the regulation of neurotransmission in the brain. This interaction may help to explain the effects of FBXW11 on brain function and behavior.

Another way that FBXW11 interacts with GPCRs is through its ability to modulate the activity of other proteins that are involved in cellular signaling pathways. For example, studies have shown that FBXW11 can interact with the protein known as TrkB, which is involved in the regulation of neurotransmission in the brain. This interaction may help to explain the effects of FBXW11 on the brain and nervous system.

In addition to its potential role as a drug target, FBXW11 also has potential as a biomarker. Its expression has been shown to be involved in a number of different diseases and disorders, including Alzheimer's disease, depression, and neurodegenerative diseases. This may make it an useful tool for the diagnosis and treatment of these conditions.

Overall, FBXW11 is a protein that has the potential to be a drug target and a biomarker. Its interaction with GPCRs and its ability to modulate the activity of other proteins make it an attractive candidate for further study and potential clinical use.

Protein Name: F-box And WD Repeat Domain Containing 11

Functions: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (PubMed:29420262)

The "FBXW11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FBXW11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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