SUN1: A Potential Drug Target for Cellular Processes (G23353)

Target Name: SUN1

NCBI ID: G23353

SUN1

SUN1: A Potential Drug Target for Cellular Processes

SUN1 (Sad1 and UNC84 domain containing 1, transcript variant 3) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Sun family of proteins, which are known for their role in intracellular signaling. Specifically, SUN1 is involved in the regulation of cell survival and metabolism.

SUN1 has been identified as a potential drug target due to its involvement in a variety of cellular processes that are important for human health. For example, altered levels of SUN1 have been associated with the development of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Additionally, the deregulation of SUN1 has been implicated in a number of diseases, including heart failure, diabetes, and neuroinflammation.

One of the key features of SUN1 is its ability to interact with a variety of different signaling pathways. It has been shown to play a role in a number of signaling pathways that are important for cellular processes such as cell growth, apoptosis, and inflammation. For example, studies have shown that SUN1 can interact with the signaling pathway known as the TGF-β pathway, which is involved in the regulation of cell growth and differentiation.

In addition to its role in signaling pathways, SUN1 has also been shown to play a role in the regulation of cellular processes that are important for cell survival. For example, studies have shown that SUN1 can interact with the protein Bcl-2, which is involved in the regulation of cell apoptosis. This interaction between SUN1 and Bcl-2 suggests that SUN1 may be a potential drug target for diseases that are characterized by the dysregulation of cell apoptosis.

Another potential mechanism by which SUN1 may be involved in the regulation of cell survival is its role in the regulation of cellular processes that are important for the maintenance of cellular homeostasis. For example, studies have shown that SUN1 can interact with the protein known as Trkm-1, which is involved in the regulation of cell migration. This interaction between SUN1 and Trkm-1 suggests that SUN1 may be a potential drug target for diseases that are characterized by the disruption of cellular homeostasis.

In addition to its potential role in drug targeting, SUN1 has also been shown to have a number of potential therapeutic applications. For example, studies have shown that the levels of SUN1 are elevated in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This suggests that targeting SUN1 may be a promising strategy for the development of new treatments for these diseases. Additionally, the deregulation of SUN1 has been implicated in a number of diseases, including heart failure, diabetes, and neuroinflammation. Targeting SUN1 may therefore be a promising strategy for the development of new treatments for these diseases as well.

Overall, SUN1 is a protein that has been shown to play a role in a variety of cellular processes that are important for human health. Its involvement in signaling pathways and its potential as a drug target make it an attractive target for the development of new treatments for a variety of diseases. Further research is needed to fully understand the role of SUN1 in cellular processes and its potential as a drug target.

Protein Name: Sad1 And UNC84 Domain Containing 1

Functions: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709)

The "SUN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about SUN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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