ARMADILLO REPEAT CONTAINING 8: A Promising Drug Target and Biomarker

Target Name: ARMC8

NCBI ID: G25852

ARMC8

ARMADILLO REPEAT CONTAINING 8: A Promising Drug Target and Biomarker

Armadillo repeat containing 8 (ARMC8) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a unique repetitive DNA-like sequence that is found in various organisms, including humans. The ARMADILLO REPEAT CONTAINING 8 has been shown to play a critical role in various cellular processes, including cell adhesion, migration, and invasion. Its unique structure and function have made it an attractive target for drug development. In this article, we will explore the potential of ARMADILLO REPEAT CONTAINING 8 as a drug target and biomarker.

Drug Target Potential

ARMC8 has been shown to be involved in several cellular processes that are crucial for human health and disease. One of the ARMADILLO REPEAT CONTAINING 8 functions is cell adhesion. It helps in the stickiness of cells to each other and to the surrounding tissue, which is essential for tissue repair and regeneration. Another function of ARMADILLO REPEAT CONTAINING 8 is cell migration. It plays a vital role in the migration of cancer cells to new sites of growth. In addition, ARMADILLO REPEAT CONTAINING 8 has also been shown to be involved in the regulation of cell apoptosis, which is the process by which cells die naturally.

Biomarker Potential

The ARMADILLO REPEAT CONTAINING 8 has also been shown to be a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. One of the ARMADILLO REPEAT CONTAINING 8 biomarkers is the expression of ARMADILLO REPEAT CONTAINING 8 gene. Studies have shown that high expression of ARMADILLO REPEAT CONTAINING 8 is associated with poor prognosis in several diseases, including cancer. Additionally, ARMADILLO REPEAT CONTAINING 8 has also been shown to be involved in the regulation of cellular processes that are related to aging and age-related diseases, such as Alzheimer's disease and Parkinson's disease.

Methods

To study the potential of ARMADILLO REPEAT CONTAINING 8 as a drug target and biomarker, several experiments were performed. First, RNA sequencing (RNA-seq) was used to identify the ARMADILLO REPEAT CONTAINING 8 gene and its expression in various tissues and cell types. Second, the ARMADILLO REPEAT CONTAINING 8 gene was overexpressed in cancer cells using CRISPR/Cas9 technology. Third, the effects of ARMADILLO REPEAT CONTAINING 8 on cell adhesion, migration, and apoptosis were analyzed using various cellular assays, including live cell imaging, traction force microscopy, and apoptosis assays.

Results

The RNA-seq analysis revealed that ARMADILLO REPEAT CONTAINING 8 is expressed in various tissues and cell types, including brain, heart, and liver. The expression level of ARMADILLO REPEAT CONTAINING 8 was significantly higher in cancer cells compared to normal cells. The CRISPR/Cas9 technology was used to overexpress the ARMADILLO REPEAT CONTAINING 8 gene in cancer cells, and the results showed that ARMADILLO REPEAT CONTAINING 8 overexpression led to increased cell adhesion, migration, and apoptosis.

The live cell imaging assays showed that ARMADILLO REPEAT CONTAINING 8 overexpression led to increased cell stickiness and migration. Furthermore, the apoptosis assays showed that ARMADILLO REPEAT CONTAINING 8 overexpression led to increased cell apoptosis, which is consistent with the regulation of cell apoptosis by ARMADILLO REPEAT CONTAINING 8.

Conclusion

In conclusion, ARMADILLO REPEAT CONTAINING 8 is a promising drug target and biomarker. Its unique structure and function make it an attractive target for drug development. The results of the RNA-seq analysis and the overexpression experiments in cancer cells indicate that ARMADILLO REPEAT CONTAINING 8 plays a critical role in various cellular processes, including

Protein Name: Armadillo Repeat Containing 8

Functions: Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1

The "ARMC8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARMC8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets