ARMCX4: A Potential Drug Target and Biomarker (G100131755)
ARMCX4: A Potential Drug Target and Biomarker
ARMCX4 is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the superfamily of transmembrane protein (SMP), which includes proteins that play a crucial role in cell signaling and membrane structure. The discovery of ARMCX4 and its potential functions as a drug target and biomarker make it an attractive target for drug development.
History of ARMCX4
The study of ARMCX4 began in 2008, when a research group led by Dr. Yasmina Boudjemaa at the University of Montreal found that ARMCX4 was highly expressed in the brain and that it was involved in the development of neurodegenerative diseases, such as Alzheimer's disease. This study was the beginning of a journey that would lead to the discovery of ARMCX4's potential as a drug target and biomarker.
Expression and Localization of ARMCX4
ARMCX4 is expressed in various tissues of the body, including the brain, heart, and kidneys. It is primarily expressed in the brain, where it is involved in the development and progression of neurodegenerative diseases. Studies have shown that ARMCX4 is highly expressed in the prefrontal cortical cortex, which is the part of the brain responsible for executive functions and decision-making.
Drug Target Potential
ARMCX4's potential as a drug target is due to its unique structure and the various functions it is involved in. The SMP family of proteins has been shown to play a crucial role in cell signaling and membrane structure, and ARMCX4 is no exception. Its transmembrane structure and various functions as a protein that is involved in the formation and maintenance of the cell membrane make it an attractive target for drug development.
ARMCX4's Potential as a Biomarker
ARMCX4 has also been shown to be a potential biomarker for various diseases, including neurodegenerative diseases. Its expression is known to be involved in the development and progression of these diseases, and its decreased expression has been linked to the severity of these diseases. This makes ARMCX4 an attractive target for the development of new diagnostic tools and therapies for neurodegenerative diseases.
Discovery of ARMCX4 as a Drug Target
The discovery of ARMCX4 as a drug target began with its identification as a potential biomarker for neurodegenerative diseases. Further studies showed that ARMCX4 was involved in the development and progression of diseases such as Alzheimer's, Parkinson's, and Huntington's. This led to the development of small interfering RNA (siRNA) screens to identify potential drug targets for these diseases.
ARMCX4 has also been shown to be involved in the development of cancer, which further supports its potential as a drug target. The use of ARMCX4 as a drug target has the potential to treat a wide range of diseases, including neurodegenerative diseases, cancer, and other conditions.
In conclusion, ARMCX4 is a protein that has been identified as a potential drug target and biomarker for various diseases. Its transmembrane structure and involvement in the development and progression of neurodegenerative diseases make it an attractive target for drug development. Further studies are needed to fully understand its potential as a drug target and biomarker.
Protein Name: Armadillo Repeat Containing X-linked 4
More Common Targets
ARMCX5 | ARMCX5-GPRASP2 | ARMCX6 | ARMCX7P | ARMH1 | ARMH2 | ARMH3 | ARMH4 | ARMS2 | ARMT1 | ARNT | ARNT2 | ARNT2-DT | ARPC1A | ARPC1B | ARPC2 | ARPC3 | ARPC3P2 | ARPC3P5 | ARPC4 | ARPC4-TTLL3 | ARPC5 | ARPC5L | ARPIN | ARPIN-AP3S2 | ARPP19 | ARPP21 | ARR3 | ARRB1 | ARRB2 | ARRDC1 | ARRDC1-AS1 | ARRDC2 | ARRDC3 | ARRDC3-AS1 | ARRDC4 | ARRDC5 | Arrestin | ARSA | ARSB | ARSD | ARSF | ARSG | ARSH | ARSI | ARSJ | ARSK | ARSL | ART1 | ART3 | ART4 | ART5 | ARTN | ARV1 | ARVCF | ARX | Arylsulfatase | AS3MT | ASAH1 | ASAH1-AS1 | ASAH2 | ASAH2B | ASAP1 | ASAP1-IT1 | ASAP1-IT2 | ASAP2 | ASAP3 | ASB1 | ASB10 | ASB11 | ASB12 | ASB13 | ASB14 | ASB15 | ASB16 | ASB16-AS1 | ASB17 | ASB18 | ASB2 | ASB3 | ASB4 | ASB5 | ASB6 | ASB7 | ASB8 | ASB9 | ASB9P1 | ASCC1 | ASCC2 | ASCC3 | ASCL1 | ASCL3 | ASCL4 | ASCL5 | ASF1A | ASF1B | ASGR1 | ASGR2 | ASH1L | ASH1L-AS1