ARMC5: A Potential Drug Target for Cancer, Neurodegenerative Diseases and Cardiovascular Disease

Target Name: ARMC5

NCBI ID: G79798

ARMC5

ARMC5: A Potential Drug Target for Cancer, Neurodegenerative Diseases and Cardiovascular Disease

Armadillo repeat-containing protein 5 (ARMC5) is a protein that is expressed in a variety of tissues, including skeletal muscles, heart, brain, and kidney. It is a member of the armadillo repeat family of proteins, which are characterized by the presence of a specific repeat sequence in the protein sequence. ARMC5 is of particular interest as a potential drug target or biomarker, due to its unique structure and the involvement of several diseases.

Structure and Functions

ARMC5 is a 126 amino acid protein that is expressed in a variety of tissues. It is highly conserved, with a calculated alpha-helical score of 66.9% and a predicted localization in the cytoplasm of 66%. The protein has a unique structure, with a long N-terminus that is rich in conserved acidic and basic residues. The N-terminus contains a putative transmembrane domain that is involved in protein-protein interactions and may be involved in the regulation of cellular processes.

One of the most notable features of ARMC5 is its role in the regulation of muscle mass and function. It is a key protein in the regulation of muscle protein synthesis and degradation, and is involved in the development and maintenance of muscle mass. ARMC5 has been shown to play a role in the regulation of muscle protein synthesis and degradation in a variety of organisms, including humans.

In addition to its role in muscle regulation, ARMC5 is also involved in several other processes in the body. It is a potent antioxidant, and has been shown to protect against oxidative stress in a variety of cell types. It is also involved in the regulation of cellular signaling processes, and has been shown to play a role in the regulation of cell proliferation and differentiation.

Disease association

ARMC5 is involved in several diseases and conditions, including cancer, neurodegenerative diseases, and cardiovascular disease. Its involvement in these diseases has led to its potential as a drug target or biomarker.

In cancer, ARMC5 has been shown to be involved in the regulation of cell growth, angiogenesis, and the development of resistance to chemotherapy. It has also been shown to play a role in the regulation of cell cycle progression and the maintenance of stem cell properties. As a result, ARMC5 has been shown to be a potential target for cancer therapies that target these processes.

In neurodegenerative diseases, ARMC5 has been shown to be involved in the regulation of neurotransmitter synthesis and release, as well as the regulation of cellular signaling processes. Its involvement in these processes has led to its potential as a biomarker for the diagnosis and progression of neurodegenerative diseases.

In cardiovascular disease, ARMC5 has been shown to be involved in the regulation of cellular signaling processes, as well as the regulation of inflammation. Its involvement in these processes has led to its potential as a target for therapies that target these processes.

ARMC5 as a drug target

ARMC5's unique structure and the involvement of several diseases make it an attractive target for drug development. Several studies have shown that ARMC5 can be targeted by small molecules, including inhibitors of protein-protein interactions and inhibitors of antioxidant pathways.

One potential approach to targeting ARMC5 is the use of small molecules that can inhibit protein-protein interactions. This would involve targeting the N-terminus of the protein, which is rich in conserved acidic and basic residues that are involved in these interactions. Compounds that are able to inhibit these interactions would be expected to have the potential to block the activity of ARMC5.

Another potential approach to targeting ARMC5 is the use of small molecules that can inhibit antioxidant pathways. This would involve targeting the N-terminus of the protein, which is involved in the regulation of antioxidant enzymes. Compounds that are able to inhibit these enzymes

Protein Name: Armadillo Repeat Containing 5

Functions: Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429)

The "ARMC5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARMC5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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