CHST5: A Potential Drug Target and Biomarker (G23563)

Target Name: CHST5

NCBI ID: G23563

CHST5

CHST5: A Potential Drug Target and Biomarker

CHST5, or carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5, is a gene that encodes a protein in the SLCO family of transport proteins. This protein is involved in the transport of carbohydrates, including glucose, across cell membranes. CHST5 is expressed in many different tissues and cells throughout the body, including the brain, heart, and kidneys.

The function of CHST5 is to transport carbohydrates across cell membranes using its unique structure. CHST5 has a transmembrane domain that is responsible for its ability to interact with carbohydrates and transport them across the membrane. Additionally, CHST5 has a cytoplasmic domain that is involved in its localization to the endoplasmic reticulum (ER) and its subsequent transport to other cellular compartments.

CHST5 is a critical protein for the proper functioning of many different cellular processes in the body. For example, it is involved in the uptake and storage of glucose in the brain, which is essential for maintaining proper brain function. Additionally, CHST5 is involved in the export of proteins from the ER to the cytoplasm, which is important for the proper functioning of many different cellular processes.

Due to its involvement in so many different cellular processes, CHST5 has been identified as a potential drug target. Researchers are currently exploring the use of drugs that can modulate the activity of CHST5 in order to treat a variety of different diseases. For example, some researchers are investigating the use of drugs that can inhibit the activity of CHST5 in order to treat diabetes, while others are studying the potential uses of drugs that can modulate the activity of CHST5 in order to treat other diseases such as heart disease and neurodegenerative disorders.

In addition to its potential as a drug target, CHST5 has also been identified as a potential biomarker. Researchers are studying the expression and activity of CHST5 to see how they can be used as a tool for the diagnosis and prognosis of various diseases. For example, some researchers are using CHST5 as a potential biomarker to study the effects of different treatments on the progression of neurodegenerative disorders, while others are using CHST5 as a potential biomarker to study the effects of different treatments on the development of heart disease.

Overall, CHST5 is a protein that is involved in the transport of carbohydrates across cell membranes. Its unique structure and involvement in many different cellular processes make it a potential drug target and biomarker. As research continues to advance, the potential uses of CHST5 will continue to grow and evolve.

Protein Name: Carbohydrate Sulfotransferase 5

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for SELL. Its substrate specificity may be influenced by its subcellular location

The "CHST5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CHST5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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