FBXO33: A Potential Drug Target and Biomarker (G254170)

Target Name: FBXO33

NCBI ID: G254170

FBXO33

FBXO33: A Potential Drug Target and Biomarker

Fbx33 (Fbx33) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. Its full name is Facebooker domain-containing 33kDa protein, and it is a member of the superfamily of proteins known as the Fbx proteins. Fbx proteins are known for their ability to form a protein-protein interaction network, which is important for various cellular processes, including cell signaling and protein folding.

One of the unique features of Fbx33 is its ability to interact with the protein p120GAP, which is a known regulator of protein-protein interactions. This interaction between Fbx33 and p120GAP has been shown to play a role in the regulation of various cellular processes, including cell signaling, neurodegeneration, and diseases such as cancer.

Fbx33 has also been shown to interact with other proteins, including the protein kinase PDK4. This interaction between Fbx33 and PDK4 has been shown to play a role in the regulation of cell proliferation, and is a potential drug target for cancer treatment.

In addition to its potential role as a drug target, Fbx33 has also been shown to be a potential biomarker for various diseases. For example, Fbx33 has been shown to be expressed in the brains of individuals with Alzheimer's disease, and its levels have been shown to be decreased in individuals with this disease. This suggests that Fbx33 may be a useful biomarker for the diagnosis and treatment of Alzheimer's disease.

Fbx33 has also been shown to be expressed in the kidneys of individuals with diabetic nephropathy, a common form of diabetes that can cause kidney damage. This suggests that Fbx33 may be a useful biomarker for the diagnosis and treatment of diabetic nephropathy.

In conclusion, Fbx33 is a protein that has been shown to interact with various proteins and to play a role in the regulation of various cellular processes. Its potential as a drug target and biomarker make it an attractive target for further research and development. Further studies are needed to fully understand the role of Fbx33 in various cellular processes and to determine its potential as a drug or biomarker.

Protein Name: F-box Protein 33

Functions: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1 (By similarity)

The "FBXO33 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FBXO33 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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