FBXO5: A Potential Cancer Therapeutic Target? (G26271)

Target Name: FBXO5

NCBI ID: G26271

FBXO5

FBXO5: A Potential Cancer Therapeutic Target?

FBXO5, also known as F-box protein 5, is a protein that is expressed in a wide range of tissues and cells in the human body. It is a member of the F-box protein family, which is a family of proteins that contain a conserved structural motif known as an F-box. These proteins are involved in a variety of cellular processes, including cell signaling, DNA replication, and cellular stress resistance.

One of the unique features of FBXO5 is its ability to interact with the protein known as p53, which is a tumor suppressor protein that is involved in the regulation of cell growth and division. This interaction between FBXO5 and p53 has led some researchers to consider FBXO5 as a potential drug target or biomarker for cancer.

In addition to its potential role as a drug target or biomarker, FBXO5 has also been shown to play a role in the regulation of cellular processes that are important for normal development and function. For example, studies have shown that FBXO5 is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs.

FBXO5 has also been shown to be involved in the regulation of cellular signaling pathways that are important for normal development and function. For example, studies have shown that FBXO5 is involved in the regulation of the signaling pathway known as the TGF-β pathway, which is involved in the regulation of cell growth and differentiation.

In addition to its role in cellular signaling, FBXO5 has also been shown to play a role in the regulation of cellular stress resistance. This is the ability of cells to withstand and recover from environmental stressors, such as radiation or chemical insults.

As a potential drug target or biomarker, FBXO5 is of interest because of its ability to interact with the protein known as p53, as well as its involvement in the regulation of cellular processes that are important for normal development and function. This suggests that it may be a useful target for the development of new cancer therapies, as well as for the diagnosis and treatment of a variety of other diseases.

In conclusion, FBXO5 is a protein that has been shown to play a role in a variety of cellular processes that are important for normal development and function. Its ability to interact with the protein known as p53, as well as its involvement in the regulation of cellular signaling pathways and stress resistance, make it of interest as a potential drug target or biomarker for cancer. Further research is needed to fully understand the role of FBXO5 in these processes, as well as its potential as a therapeutic agent.

Protein Name: F-box Protein 5

Functions: Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During mitotic cell cycle plays a role as both substrate and inhibitor of APC-FZR1 complex (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment (PubMed:29875408). As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box coreceptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and chain elongation by APC by preventing the UBE2C and UBE2S activities (PubMed:23708605, PubMed:23708001, PubMed:16921029). Plays a role in genome integrity preservation by coordinating DNA replication with mitosis through APC inhibition in interphase to stabilize CCNA2 and GMNN in order to promote mitosis and prevent rereplication and DNA damage-induced cellular senescence (PubMed:17234884, PubMed:17485488, PubMed:17875940). During oocyte maturation, plays a role in meiosis through inactivation of APC-FZR1 complex. Inhibits APC through RPS6KA2 interaction that increases FBXO5 affiniy for CDC20 leading to the metaphase arrest of the second meiotic division before fertilization (By similarity). Controls entry into the first meiotic division through inactivation of APC-FZR1 complex (By similarity). Promotes migration and osteogenic differentiation of mesenchymal stem cells (PubMed:29850565)

The "FBXO5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FBXO5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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