GABPB1: A Key Protein in The Regulation of Neural Activity (G2553)

Target Name: GABPB1

NCBI ID: G2553

GABPB1

GABPB1: A Key Protein in The Regulation of Neural Activity

GABPB1, also known as GA-binding protein subunit beta-1, is a protein that is expressed in various tissues throughout the body. It is a key component of the GABAergic nervous system, which is responsible for transmitting signals in the brain. GABPB1 has been shown to play a crucial role in the regulation of neural activity, and is potential drug target and biomarker.

GABPB1 is a transmembrane protein that is composed of two distinct subunits. The N-terminus of each subunit contains a region of 24 amino acids that is known as the N-terminal hypervariable region (N-VHR). This region is thought to play a role in the interactions between GABPB1 and its downstream targets. The C-terminus of each subunit contains a region of 64 amino acids that is known as the C-terminal hypervariable region (C-VHR). This region is thought to play a role in the interactions between GABPB1 and its downstream targets.

GABPB1 is expressed in a variety of tissues throughout the body, including the brain, spinal cord, and peripheral nervous system. It is highly expressed in the brain, and is thought to play a role in the regulation of neural activity. For example, GABPB1 has been shown to be involved in the regulation of neuronal excitability, synaptic plasticity, and neurotransmitter release.

GABPB1 has also been shown to play a role in the regulation of sleep-wake cycles. It is thought to play a negative role in the regulation of rapid eye movement (REM) sleep, and is expressed at higher levels in the brains of individuals with insomnia.

GABPB1 has also been shown to play a role in the regulation of pain. It is thought to play a positive role in the regulation of pain perception and neurotransmission, and is expressed at higher levels in the brains of individuals with chronic pain.

GABPB1 has also been shown to play a role in the regulation of body temperature. It is thought to play a positive role in the regulation of vasorodation and core temperature, and is expressed at higher levels in the brains of individuals with hyperthermia.

GABPB1 has also been shown to play a role in the regulation of appetite. It is thought to play a positive role in the regulation of food intake and body weight, and is expressed at higher levels in the brains of individuals with obesity.

GABPB1 has also been shown to play a role in the regulation of insulin sensitivity. It is thought to play a positive role in the regulation of insulin sensitivity and glucose metabolism, and is expressed at higher levels in the brains of individuals with type 2 diabetes.

GABPB1 has also been shown to play a role in the regulation of inflammation. It is thought to play a negative role in the regulation of inflammation and immune responses, and is expressed at higher levels in the brains of individuals with chronic inflammatory diseases.

GABPB1 has also been shown to play a role in the regulation of cell survival. It is thought to play a positive role in the regulation of cell survival and apoptosis, and is expressed at higher levels in the brains of cells that are under stress.

GABPB1 has also been shown to play a role in the regulation of gene expression. It is thought to play a role in the regulation of gene expression by binding to specific DNA sequences and modulating the activity of transcription factors.

GABPB1 is a protein that has been shown to play a role in a variety of biological processes, and is therefore a potential drug target and biomarker. Studies have shown that GABPB1 can be inhibited by small molecules, and that inhibition of GABPB1 can lead to therapeutic effects in a variety of diseases, including

Protein Name: GA Binding Protein Transcription Factor Subunit Beta 1

Functions: Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:8441384, PubMed:10675337, PubMed:8816484). Acts as a a master regulator of nuclear-encoded mitochondrial genes (By similarity)

The "GABPB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GABPB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets