GABRA2: A Potential Drug Target and Biomarker for neurological disorders

Target Name: GABRA2

NCBI ID: G2555

GABRA2

GABRA2: A Potential Drug Target and Biomarker for neurological disorders

GABRA2, or Gamma-aminobutyric acid receptor subunit alpha-2 (isoform b), is a transmembrane protein that plays a crucial role in the function of the nervous system. It is a G protein-coupled receptor (GPCR), which means it interacts with intracellular signaling molecules known as G proteins. GABRA2 is expressed in many different tissues and cells throughout the body, including the brain, and is involved in a wide range of physiological processes, including neurotransmission, learning, and memory.

Recent research has identified GABRA2 as a potential drug target for a variety of neurological disorders. For example, GABRA2 has been shown to be involved in the development and progression of several neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. In addition, GABRA2 has also been implicated in a variety of other neurological disorders, including depression, anxiety, and schizophrenia.

One of the key challenges in studying GABRA2 as a drug target is its complex structure and function. GABRA2 is a large protein that contains multiple domains, including an extracellular domain, a transmembrane domain, and an intracellular domain. The transmembrane domain is responsible for the protein's ability to interact with intracellular signaling molecules, while the intracellular domain is responsible for its ability to interact with these molecules.

Recent studies have provided valuable insights into the structure and function of GABRA2. For example, researchers have shown that GABRA2 contains a conserved region known as the N-terminus that is involved in its interactions with G proteins. Additionally, studies have shown that GABRA2 contains a region known as the 伪-helix that is involved in its stability and function.

Another promising aspect of GABRA2 is its potential as a biomarker. GABRA2 has been shown to be expressed in a variety of tissues and cells, including brain, and may be a useful biomarker for certain neurological disorders. For example, researchers have shown that GABRA2 is expressed in the brains of individuals with Alzheimer's disease and that it may be a potential diagnostic biomarker for this disorder.

In addition, GABRA2 has also been shown to be involved in a variety of physiological processes that are important for brain health and function. For example, GABRA2 is involved in neurotransmission, which is the process by which nerve impulses are transmitted from the brain to the rest of the body. Additionally, GABRA2 is involved in learning and memory, which are important processes for the brain that are critical for human cognition and behavior.

GABRA2 is also involved in the regulation of pain and anxiety. Studies have shown that GABRA2 is involved in the modulation of pain perception and that it may be a potential target for the treatment of chronic pain. Additionally, GABRA2 has also been implicated in the regulation of anxiety and that it may be a potential target for the treatment of anxiety disorders.

In conclusion, GABRA2 is a protein that plays a crucial role in the function of the nervous system. Recent research has identified GABRA2 as a potential drug target for a variety of neurological disorders and as a potential biomarker for these disorders. Further research is needed to fully understand the role of GABRA2 in neurological function and to develop effective treatments for the disorders associated with its dysfunction.

Protein Name: Gamma-aminobutyric Acid Type A Receptor Subunit Alpha2

Functions: Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:29961870, PubMed:31032849). Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:29961870, PubMed:31032849). The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity). The alpha2/beta2/gamma2 receptor exhibits synaptogenic activity whereas the alpha2/beta3/gamma2 receptor shows very little or no synaptogenic activity (By similarity)

The "GABRA2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GABRA2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets