ENOPH1: A Potential Drug Target for Neurodegenerative Disorders

Target Name: ENOPH1

NCBI ID: G58478

ENOPH1

ENOPH1: A Potential Drug Target for Neurodegenerative Disorders

ENOPH1 (MST145) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the ENOPHAMMEL gene family, which is known for its role in the regulation of intracellular signaling pathways.

One of the functions of ENOPH1 is to regulate the activity of the protein Pyh, which is involved in the production of reactive oxygen species (ROS) that can cause damage to cells and contribute to various diseases, including neurodegenerative disorders.

Pyh is a transcription factor that regulates the expression of many genes, including those involved in cell signaling pathways, DNA repair, and stress response. It is activated by ROS, which are generated by cellular processes such as metabolism, inflammation, and cellular stress.

ENOPH1 helps to regulate the activity of Pyh by recruiting it to the endoplasmic reticulum (ER) and preventing it from being degraded by the ubiquitin-proteasome system (UPS). This allows Pyh to maintain its activity and influence the expression of target genes.

In addition to its role in regulating Pyh activity, ENOPH1 may also be a drug target or biomarker. For example, it has been shown to be involved in the development of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease.

Research has also suggested that ENOPH1 may be a potential therapeutic target for these disorders. By inhibiting the activity of Pyh, ENOPH1 may be able to reduce the production of ROS and protect against the damage caused by these reactive oxygen species.

Furthermore, ENOPH1 has also been shown to be involved in the regulation of cellular stress responses, which are critical for maintaining tissue homeostasis and promoting overall cellular health. This may make it an attractive target for strategies aimed at preventing or treating cellular stress-related diseases.

In conclusion, ENOPH1 is a protein that plays a critical role in the regulation of intracellular signaling pathways and is expressed in various tissues of the body. Its role in regulating the activity of Pyh and in the regulation of cellular stress responses makes it an attractive target for drug development aimed at preventing or treating neurodegenerative disorders and cellular stress-related diseases. Further research is needed to fully understand the mechanisms of ENOPH1's role in these processes and to develop effective therapies based on this protein.

Protein Name: Enolase-phosphatase 1

Functions: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)

The "ENOPH1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ENOPH1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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