FBL2: Regulation of Muscle Growth and Maintenance (G25827)

Target Name: FBXL2

NCBI ID: G25827

FBXL2

FBL2: Regulation of Muscle Growth and Maintenance

The F-box protein FBL2 (F Box-like 2) is a member of the F-box protein family, which are a family of proteins that contain a specific structural domain known as an F-box. FBL2 is a 21 kDa protein that is expressed in a variety of tissues, including muscle, nerve, and heart. It is also known as FBL3.

The F-box protein family plays a crucial role in the regulation of various cellular processes, including cell growth, differentiation, and metabolism. FBL2 is involved in these processes as well, and is thought to play a key role in the regulation of muscle growth and maintenance.

One of the unique features of FBL2 is its ability to interact with other proteins. It can form a complex with the protein Myosin regulatory protein of muscle, which is important for muscle contraction. This interaction between FBL2 and Myosin regulatory protein is thought to be involved in the regulation of muscle growth and maintenance.

Another interesting property of FBL2 is its ability to interact with the protein heat shock protein HSP70. HSP70 is a protein that is involved in the regulation of various cellular processes, including stress response and DNA damage repair. FBL2 can form a complex with HSP70, which is thought to be involved in the regulation of stress response and DNA damage repair.

FBL2 is also known as FBL3, and it is thought to be involved in the regulation of various cellular processes, including cell growth, differentiation, and metabolism. It is expressed in a variety of tissues, including muscle, nerve, and heart.

In addition to its role in the regulation of cellular processes, FBL2 is also thought to be involved in the development and maintenance of various diseases. For example, it is has been shown to be involved in the development of cancer, and may also be involved in the regulation of aging.

Despite its importance, the regulation of FBL2 is not well understood. It is not known why FBL2 is expressed in various tissues, or how it contributes to the regulation of cellular processes. Further research is needed to better understand the role of FBL2 in the regulation of cellular processes and the development and maintenance of various diseases.

In conclusion, the F-box protein FBL2 (F Box-like 2) is a protein that is involved in the regulation of various cellular processes, including cell growth, differentiation, and metabolism. It is also thought to play a key role in the regulation of muscle growth and maintenance, and in the development and maintenance of various diseases. Further research is needed to better understand its role in these processes and to identify potential drug targets or biomarkers.

Protein Name: F-box And Leucine Rich Repeat Protein 2

Functions: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:22020328, PubMed:22323446). Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin (PubMed:22020328, PubMed:22323446). This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin (PubMed:22020328, PubMed:22323446). Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (PubMed:22020328, PubMed:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PubMed:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (By similarity). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (PubMed:26037928)

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