FBXO27: A Potential Drug Target and Biomarker (G126433)

Target Name: FBXO27

NCBI ID: G126433

FBXO27

FBXO27: A Potential Drug Target and Biomarker

Introduction

F-unstable proteins (F-unstable proteins, FSPs) are a class of proteins that are highly abundant in cells and play an important role in cell cycle and growth regulation. FBXO27 is a member of the FSPs family and plays an important role in various cancers. Mutations in the FBXO27 gene can cause a variety of diseases, including neurodegenerative diseases, blood diseases, liver diseases, and immune system diseases. Therefore, studying FBXO27 as a drug target has important clinical significance. This article will introduce the role of FBXO27, the mechanism of tumorigenesis, and its potential and challenges as a drug target.

The role of FBXO27

FBXO27 is a transferrin that belongs to the FSPs family. Its main function is to transport and regulate the concentration of iron ions in cells, thereby participating in many important biological processes within cells, such as cell proliferation, differentiation and tumorigenesis. FBXO27 plays a role in a variety of cancers, such as neurodegenerative diseases, blood diseases, liver diseases, and immune system diseases. By regulating iron ion concentration, FBXO27 can affect intracellular signaling pathways, such as neurotransmitter receptors, cell cycle regulation, and tumorigenesis.

The tumorigenesis mechanism of FBXO27

The role of FBXO27 in tumorigenesis is unclear, but studies have shown that FBXO27 may play multiple roles in tumorigenesis. First, FBXO27 can affect the growth and proliferation of tumor cells. Secondly, FBXO27 can regulate the cell cycle and thereby control the growth and spread of tumor cells. In addition, FBXO27 can also affect the apoptosis of tumor cells, thus having potential significance in tumor treatment.

Potential and challenges of FBXO27 as a drug target

Although studying FBXO27 as a drug target has important clinical significance, FBXO27 faces some challenges as a drug target. First, FBXO27 is a protein, so studying FBXO27 as a drug target requires revealing its unique biological properties. Secondly, studying FBXO27 as a drug target requires determining its mechanism of action in order to develop effective drugs. In addition, studying FBXO27 as a drug target also requires determining its mechanism of action in different types of tumors.

in conclusion

FBXO27 is a protein with high intracellular content and plays an important role in cell cycle and growth regulation. FBXO27 plays an important role in a variety of cancers, such as neurodegenerative diseases, blood diseases, liver diseases, and immune system diseases. Therefore, studying FBXO27 as a drug target has important clinical significance. Although research on FBXO27 as a drug target faces some challenges, with the deepening of research, FBXO27 as a drug target can bring better therapeutic effects to tumor patients.

Protein Name: F-box Protein 27

Functions: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
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•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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