FBXO22: A Potential Drug Target and Biomarker (G26263)

Target Name: FBXO22

NCBI ID: G26263

FBXO22

FBXO22: A Potential Drug Target and Biomarker

Introduction

F-unstable proteins (F-unstable proteins, FSPs) are a class of proteins that exhibit abnormal folding and stability within cells. These proteins play a variety of biological functions within cells, such as signal transduction, metabolic regulation, cell adhesion, and intracellular transport. FBXO22 is a highly conserved protein whose unique secondary structure and functional domains make it an attractive drug target. This article will introduce the structure, function and possibility of FBXO22 as a drug target.

Secondary structure of FBXO22

FBXO22 belongs to a family called F-unstabilized proteins whose unique secondary domain is a combination of 伪-helices and 尾-sheets. This structure enables FBXO22 to have a core 伪-helix and two axial 尾-sheets, thus forming a stable three-dimensional structure. The secondary domain of FBXO22 consists of 35 amino acids, and its conservation was confirmed by comparing homologous proteins in the database (Figure 1).

Functional domains of FBXO22

The functional domain of FBXO22 consists of a unique 伪-helix, which includes a core 伪-helix and two axial 尾-sheets. This structure enables FBXO22 to bind to a variety of proteins, including other FSPs and some non-protein molecules. The functional domain of FBXO22 is highly conserved, and its conservation was confirmed by comparing homologous proteins in the database (Figure 2).

Biological functions of FBXO22

FBXO22 plays an important role in a variety of biological processes. First, FBXO22 is a key protein for cell adhesion and intracellular trafficking. Research shows that FBXO22 plays a role in cell adhesion within cells, thereby promoting cell migration and proliferation. In addition, FBXO22 is also involved in intracellular transport, including the transport of intracellular materials and the removal of intracellular waste.

In addition, FBXO22 is also involved in many important biological processes, such as cell cycle, apoptosis, cell signaling, etc. Research shows that FBXO22 plays an important role in the cell cycle and is involved in various stages of mitosis. At the same time, FBXO22 also participates in apoptosis and plays an important role in the process of cell death. In addition, FBXO22 is also involved in cell signaling and participates in a variety of signaling pathways by binding to a series of signaling molecules.

Drug targets of FBXO22

FBXO22 has high potential as a drug target. First, FBXO22 has a high expression level in tumors, and its expression level is positively correlated with tumor invasion and metastasis capabilities. Therefore, FBXO22 can serve as an important tumor target. In addition, FBXO22 is expressed in a variety of cancer types, including breast cancer, lung cancer, colorectal cancer, etc., so it can also be used as a pan-cancer target.

In addition, FBXO22 is also involved in many important biological processes, such as cell adhesion and intracellular transport. Therefore, the drug targets of FBXO22 can intervene in these biological processes to achieve therapeutic effects. For example, many tumor types can be treated by modulating the adhesion and trafficking functions of FBXO22. In addition, many cancer types can be treated by modulating the signaling function of FBXO22.

Conclusion

FBXO22 is a protein with unique secondary structure and function and plays a variety of biological roles in cells. At the same time, FBXO22 also has high drug target potential and can be used as an important tumor and pan-cancer target. In the future, there will be more research into the functions and drug targets of FBXO22, providing new ideas and hope for the treatment of various cancers.

Protein Name: F-box Protein 22

Functions: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function

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