NUPR1: A Protein Targeted for Cancer, Neurodegenerative Diseases and Immune Disorders

Target Name: NUPR1

NCBI ID: G26471

NUPR1

NUPR1: A Protein Targeted for Cancer, Neurodegenerative Diseases and Immune Disorders

Nuclear Protein 1 (ISOform A), also known as NUPR1, is a protein that is expressed in almost all eukaryotic cells, including mammals, birds, fish, and fungi. Its function plays a vital role in the nucleus and is an important participant in gene expression and regulation in cells.

In recent years, researchers have been increasingly interested in NUPR1, especially in seeking its application as a drug target or biomarker. NUPR1 plays an important role in many biological processes, including cell cycle, DNA replication, RNA splicing, chromatin structure and function, etc. In addition, NUPR1 is also closely related to the occurrence and development of many diseases, such as cancer, neurodegenerative diseases, immune disorders, etc.

Currently, NUPR1 has become the focus of many research projects. In cancer treatment, researchers are exploring how NUPR1 can be used as a target for tumor treatment. Some studies have shown that inhibiting NUPR1 can significantly inhibit the growth and spread of tumor cells. In addition, some studies have also shown that the survival rate and quality of life of tumor patients can be improved by regulating the expression level of NUPR1.

In neurodegenerative diseases, NUPR1 is also considered a potential drug target. For example, some studies have shown that inhibiting NUPR1 can slow down neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In addition, NUPR1 is also related to neuronal apoptosis and survival, therefore, regulating the expression level of NUPR1 may help treat these diseases.

NUPR1 also plays an important role in immune dysregulation. Some studies suggest that inhibiting NUPR1 can enhance immune system function, thereby improving immune health. In addition, NUPR1 is also related to the regulation of immune cell differentiation and function. Therefore, regulating the expression level of NUPR1 may help treat immune deficiency diseases.

NUPR1 plays an important role in many biological processes, therefore, it is a very attractive drug target. By inhibiting the expression level of NUPR1, many diseases can be slowed down or treated. Future research will continue to further explore the role of NUPR1 in biology and disease, and explore its potential as a drug target or biomarker.

Protein Name: Nuclear Protein 1, Transcriptional Regulator

Functions: Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in regulation of many process namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:16478804, PubMed:19650074, PubMed:16300740, PubMed:19723804, PubMed:11056169, PubMed:22858377, PubMed:11940591, PubMed:18690848, PubMed:22565310, PubMed:20181828, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4' Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the assiociation of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity)

The "NUPR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUPR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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