Zinc Finger Chromatin-Containing 3 (ZCCHC3) as A Potential Drug Target Or Biomarker

Target Name: ZCCHC3

NCBI ID: G85364

ZCCHC3

Zinc Finger Chromatin-Containing 3 (ZCCHC3) as A Potential Drug Target Or Biomarker

Zinc finger chromatin-containing 3 (ZCCHC3) is a protein that is expressed in various tissues and cells throughout the body. It is a type of zinc finger gene that is characterized by the presence of a zinc finger domain and a CCHC-type repetitive nucleotide sequence. ZCCHC3 is known to play a role in the regulation of gene expression and has been implicated in the development and progression of various diseases. As a result, ZCCHC3 has potential as a drug target or biomarker.

The zinc finger gene is a family of non-coding RNAs that are characterized by the presence of a zinc finger domain. This domain is responsible for the formation of a hairpin-like structure that can interact with specific DNA sequences. Zinc finger genes have been implicated in the regulation of gene expression by various mechanisms, including the regulation of DNA binding proteins and the modulation of chromatin structure.

One of the unique features of ZCCHC3 is its CCHC-type repetitive nucleotide sequence. This sequence consists of a series of CCAATG repeats, which are arranged in a specific pattern to form a repetitive unit. CCHC-type repeat sequences has been identified in various genomes and is thought to play a role in the regulation of gene expression.

ZCCHC3 is expressed in a variety of tissues and cells throughout the body, including the brain, heart, liver, and muscle. It is also expressed in various cell types, including stem cells, progenitor cells, and differentiative cells. ZCCHC3 has been shown to play a role in the regulation of gene expression in these cells, including the regulation of cell proliferation, differentiation, and survival.

In addition to its expression in different cell types, ZCCHC3 has also been shown to play a role in the regulation of gene expression in various biological processes. For example, ZCCHC3 has been shown to play a role in the regulation of DNA replication, which is important for the maintenance of genetic accuracy and the development of cancer. ZCCHC3 has also been shown to play a role in the regulation of apoptosis, which is the process by which cells undergo programmed cell death.

The potential drug targets for ZCCHC3 are vast and varied. One of the most promising targets is the regulation of cell proliferation. ZCCHC3 has been shown to play a role in the regulation of cell proliferation in various cell types, including stem cells and cancer cells. Therefore, drugs that can inhibit the activity of ZCCHC3 may have potential as a treatment for various types of cancer.

Another potential drug target for ZCCHC3 is the regulation of apoptosis. As mentioned earlier, ZCCHC3 has been shown to play a role in the regulation of apoptosis, which is the process by which cells undergo programmed cell death. Therefore, drugs that can induce or enhance apoptosis in a cell that is dependent on ZCCHC3 may have potential as a treatment for various types of diseases, including cancer.

In addition to its potential as a drug target or biomarker, ZCCHC3 also has potential as a research tool. The CCHC-type repetitive nucleotide sequence is a well-established genetic marker, and the use of this sequence as a research tool has led to the identification of numerous disease-related genes. By studying the expression and function of ZCCHC3, researchers may be able to gain insights into the regulation of gene expression in various diseases.

In conclusion, Zinc finger chromatin-containing 3 (ZCCHC3) is a protein that is expressed in various tissues and cells throughout the body. It is a type of zinc finger gene that is characterized by the presence of a zinc finger domain and a CCHC- type repetitive nucleotide sequence. ZCCHC3 has been shown to play a role in the regulation of gene expression and has potential as a drug target or biomarker. Further research is needed to fully understand the function of ZCCHC3 and its potential as a drug.

Protein Name: Zinc Finger CCHC-type Containing 3

Functions: Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as RIGI, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIGI-like receptors proteins RIGI and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of RIGI and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of RIGI and IFIH1/MDA5 (PubMed:30193849)

The "ZCCHC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZCCHC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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